UM  > 中華醫藥研究院
Non-ionic surfactant vesicles simultaneously enhance antitumor activity and reduce the toxicity of cantharidin
Han W.; Wang S.; Liang R.; Wang L.; Chen M.; Li H.; Wang Y.
2013
Source PublicationInternational Journal of Nanomedicine
Volume8Pages:2187
Abstract

Objective: The objective of the present study was to prepare cantharidin-entrapped non-ionic surfactant vesicles (CTD-NSVs) and evaluate their potential in enhancing the antitumor activities and reducing CTD's toxicity. Methods and results: CTD-NSVs were prepared by injection method. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and flow cytometry analysis showed that CTD-NSVs could significantly enhance in vitro toxicity against human breast cancer cell line MCF-7 and induce more significant cell-cycle arrest in G0/G1 phase. Moreover, Hoechst 33342 staining implicated that CTD-NSVs induced higher apoptotic rates in MCF-7 cells than free CTD solution. In vivo therapeutic efficacy was investigated in imprinting control region mice bearing mouse sarcoma S180. Mice treated with 1.0 mg/kg CTD-NSVs showed the most powerful antitumor activity, with an inhibition rate of 52.76%, which was significantly higher than that of cyclophosphamide (35 mg/kg, 40.23%) and the same concentration of free CTD (1.0 mg/kg, 31.05%). In addition, the acute toxicity and liver toxicity of CTD were also distinctly decreased via encapsulating into NSVs. Conclusion: Our results revealed that NSVs could be a promising delivery system for enhancing the antitumor activity and simultaneously reducing the toxicity of CTD. © 2013 Han et al, publisher and licensee Dove Medical Press Ltd.

KeywordAntitumor Activity Cantharidin Non-ionic Surfactant Vesicle Toxicity
DOI10.2147/IJN.S43568
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000320300800001
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Han W.,Wang S.,Liang R.,et al. Non-ionic surfactant vesicles simultaneously enhance antitumor activity and reduce the toxicity of cantharidin[J]. International Journal of Nanomedicine,2013,8:2187.
APA Han W..,Wang S..,Liang R..,Wang L..,Chen M..,...&Wang Y..(2013).Non-ionic surfactant vesicles simultaneously enhance antitumor activity and reduce the toxicity of cantharidin.International Journal of Nanomedicine,8,2187.
MLA Han W.,et al."Non-ionic surfactant vesicles simultaneously enhance antitumor activity and reduce the toxicity of cantharidin".International Journal of Nanomedicine 8(2013):2187.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Han W.]'s Articles
[Wang S.]'s Articles
[Liang R.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Han W.]'s Articles
[Wang S.]'s Articles
[Liang R.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Han W.]'s Articles
[Wang S.]'s Articles
[Liang R.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.