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Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells
Xu W.-S.; Dang Y.-Y.; Guo J.-J.; Wu G.-S.; Lu J.-J.; Chen X.-P.; Wang Y.-T.
2012
Source PublicationEvidence-based Complementary and Alternative Medicine
Volume2012
Abstract

Furanodiene (FUR) is a natural terpenoid isolated from Curcumae Rhizoma, a well-known Chinese medicinal herb that presents antiproliferation activities in several cancer cell lines. In this study, we demonstrated that FUR concentration dependently inhibits the cell proliferation of A549, NIH-H1299, and 95-D lung cancer cells. β-elemene, another terpenoid isolated from Curcumae Rhizoma, exhibited weaker antiproliferative effects in A549 and NIH-H1299 cells and activities similar to FUR in 95-D cells. FUR significantly inhibited colony formation in A549 and 95-D cells and upregulated both the mRNA and protein expression levels of binding immunoglobulin protein (BIP) and C/EBP homologous protein (CHOP), indicating that endoplasmic reticulum (ER) stress is induced. FUR treatment led to the accumulation of CHOP in the nucleus, which further confirms induction of ER stress. Furthermore, combined treatment of FUR with paclitaxel showed significant synergetic activities in NIH-H1299 and 95-D cells, suggesting its potential roles in combination therapy. These findings provide a basis for the further study of the anticancer effects in vivo and the internal mechanisms of FUR. © 2012 Wen-Shan Xu et al.

DOI10.1155/2012/426521
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000308200500001
The Source to ArticleScopus
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Toma's Pereira S.J., Taipa, 999078, Macau
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xu W.-S.,Dang Y.-Y.,Guo J.-J.,et al. Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells[J]. Evidence-based Complementary and Alternative Medicine,2012,2012.
APA Xu W.-S..,Dang Y.-Y..,Guo J.-J..,Wu G.-S..,Lu J.-J..,...&Wang Y.-T..(2012).Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells.Evidence-based Complementary and Alternative Medicine,2012.
MLA Xu W.-S.,et al."Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells".Evidence-based Complementary and Alternative Medicine 2012(2012).
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