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Application of Nanoparticles for Targeting G Protein-Coupled Receptors
Ma, Xin; Xiong, Yunfang; Lee, Leo Tsz On
2018-07
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume19Issue:7
Abstract

Nanoparticles (NPs) have attracted unequivocal attention in recent years due to their potential applications in therapeutics, bio-imaging and material sciences. For drug delivery, NP-based carrier systems offer several advantages over conventional methods. When conjugated with ligands and drugs (or other therapeutic molecules), administrated NPs are able to deliver cargo to targeted sites through ligand-receptor recognition. Such targeted delivery is especially important in cancer therapy. Through this targeted cancer nanotherapy, cancer cells are killed with higher specificity, while the healthy cells are spared. Furthermore, NP drug delivery leads to improved drug load, enhanced drug solubility and stability, and controlled drug release. G protein-coupled receptors (GPCRs) are a superfamily of cell transmembrane receptors. They regulate a plethora of physiological processes through ligand-receptor-binding-induced signaling transduction. With recent evidence unveiling their roles in cancer, GPCR agonists and antagonists have quickly become new targets in cancer therapy. This review focuses on the application of some notable nanomaterials, such as dendrimers, quantum dots, gold nanoparticles, and magnetic nanoparticles, in GPCR-related cancers.

Keywordg Protein-coupled Receptor (Gpcr) Cancer Nanoparticles (Nps) Dendrimers Quantum Dots (Qds) Gold Nanoparticles (Aunps) Magnetic Nanoparticles (Mnps)
DOI10.3390/ijms19072006
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000442807400185
PublisherMDPI
The Source to ArticleWOS
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationCentre of Reproduction Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Ma, Xin,Xiong, Yunfang,Lee, Leo Tsz On. Application of Nanoparticles for Targeting G Protein-Coupled Receptors[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(7).
APA Ma, Xin,Xiong, Yunfang,&Lee, Leo Tsz On.(2018).Application of Nanoparticles for Targeting G Protein-Coupled Receptors.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(7).
MLA Ma, Xin,et al."Application of Nanoparticles for Targeting G Protein-Coupled Receptors".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.7(2018).
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