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Validating antimetastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment
Niu Y.; Bai J.; Kamm R.D.; Wang Y.; Wang C.
2014
Source PublicationMolecular Pharmaceutics
Volume11Issue:7Pages:2022
Abstract

Development of new, antimetastatic drugs from natural products has been substantially constrained by the lack of a reliable in vitro screening system. Such a system should ideally mimic the native, three-dimensional (3D) tumor microenvironment involving different cell types and allow quantitative analysis of cell behavior critical for metastasis. These requirements are largely unmet in the current model systems, leading to poor predictability of the in vitro collected data for in vivo trials, as well as prevailing inconsistency among different in vitro tests. In the present study, we report application of a 3D, microfluidic device for validation of the antimetastatic effects of 12 natural compounds. This system supports co-culture of endothelial and cancer cells in their native 3D morphology as in the tumor microenvironment and provides real-time monitoring of the cells treated with each compound. We found that three compounds, namely sanguinarine, nitidine, and resveratrol, exhibited significant antimetastatic or antiangiogenic effects. Each compound was further examined for its respective activity with separate conventional biological assays, and the outcomes were in agreement with the findings collected from the microfluidic system. In summary, we recommend use of this biomimetic model system as a new engineering tool for high-throughput evaluation of more diverse natural compounds with varying anticancer potentials. © 2014 American Chemical Society.

KeywordAngiogenesis Cell Co-culture Metastasis Microfluidics Natural Products
DOI10.1021/mp500054h
URLView the original
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine ; Pharmacology & Pharmacy
WOS SubjectMedicine, Research & Experimental ; Pharmacology & Pharmacy
WOS IDWOS:000338748200011
The Source to ArticleScopus
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Cited Times [WOS]:24   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida Padre Tomas Pereira, Taipa, Macau
2.BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology (SMART) Center, 1 CREATE Way, #04-13/14 Enterprise Wing, Singapore 138602, Singapore
3.Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
Recommended Citation
GB/T 7714
Niu Y.,Bai J.,Kamm R.D.,et al. Validating antimetastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment[J]. Molecular Pharmaceutics,2014,11(7):2022.
APA Niu Y.,Bai J.,Kamm R.D.,Wang Y.,&Wang C..(2014).Validating antimetastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment.Molecular Pharmaceutics,11(7),2022.
MLA Niu Y.,et al."Validating antimetastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment".Molecular Pharmaceutics 11.7(2014):2022.
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