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Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro
Zhong Z.; Tan W.; Chen X.; Wang Y.
2014
Source PublicationEuropean Journal of Pharmacology
Volume737Pages:1
Abstract

Furanodiene is a bioactive compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin). It is one of the major components of volatile oil extracted from C. wenyujin. Furanodiene has anti-tumor activities in various cancer cell lines, as well as anti-metastatic activities. However, the underlying mechanisms of anti-metastatic activities of furanodiene have not been well investigated. In this study, we demonstrated that at low concentrations (5-25 μM), furanodiene inhibited adhesion, migration and invasion of breast cancer cells, but it did not induce cytotoxicity, apoptosis and cell cycle arrest. Furthermore, the underlying mechanisms for the anti-metastatic activity of furanodinene were also investigated. Furanodiene down-regulated the integrin αV expression, β-catenin expression, focal adhesion kinase (FAK) phosphorylation, Akt phosphorylation, and PI3 kinase p85 phosphorylation, and all of these were involved in modulation of the tumor metastasis process. In addition, an interference of metastasis was also observed in MDA-MB-231 cells through the regulation of the matrix metalloproteinase 9 (MMP-9) releases. Our results suggested that furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer. © 2014 Elsevier B.V.

KeywordBreast Cancer Furanodiene Invasion Migration Mmp-9
DOI10.1016/j.ejphar.2014.04.043
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000338706200001
The Source to ArticleScopus
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Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniversity of Macau, Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, Avenue Padre Tomas Pereira Taipa, 999078, Macau
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhong Z.,Tan W.,Chen X.,et al. Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro[J]. European Journal of Pharmacology,2014,737:1.
APA Zhong Z.,Tan W.,Chen X.,&Wang Y..(2014).Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro.European Journal of Pharmacology,737,1.
MLA Zhong Z.,et al."Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro".European Journal of Pharmacology 737(2014):1.
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