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Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza bunge in diabetic rats
Huang M.; Xie Y.; Chen L.; Chu K.; Wu S.; Lu J.; Chen X.; Wang Y.; Lai X.
2012
Source PublicationPhytotherapy Research
Volume26Issue:6Pages:944
Abstract

An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo. Copyright © 2011 John Wiley & Sons, Ltd.

KeywordDanshen Diabetes Mellitus Polyphenolic Acids Fraction Salvia Miltiorrhiza Bunge
DOI10.1002/ptr.3654
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000304816700022
The Source to ArticleScopus
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被引频次[WOS]:24   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, 350108, China
2.Institute of Drug Research and Development, Guangzhou University of Chinese Medicine, No. 232 Waihuan Road, Guangzhou 510405, China
3.College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, China
4.State Key Laboratory of Quality Research in Chinese Medicine, 999078, Macau
5.Institute of Chinese Medical Sciences, University of Macau, 999078, Macau
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Huang M.,Xie Y.,Chen L.,et al. Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza bunge in diabetic rats[J]. Phytotherapy Research,2012,26(6):944.
APA Huang M..,Xie Y..,Chen L..,Chu K..,Wu S..,...&Lai X..(2012).Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza bunge in diabetic rats.Phytotherapy Research,26(6),944.
MLA Huang M.,et al."Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza bunge in diabetic rats".Phytotherapy Research 26.6(2012):944.
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