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Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis
Afroz, Rizwana1; Cao, Yingnan2; Rostam, Muhamad Ashraf3; Ta, Hang1,4; Xu, Suowen5; Zheng, Wenhua6; Osman, Narin7; Kamato, Danielle1; Little, Peter J.1,2,7
2018-07
Source PublicationPHARMACOLOGY & THERAPEUTICS
ISSN0163-7258
Volume187Pages:88-97
Abstract

Atherosclerosis commences with the trapping of low density lipoproteins (LDLs) in blood vessels by modified proteoglycans (PGs) with hyperelongated glycosaminoglycan (GAG) chains. GAG chain synthesis and growth factor mediated hyperelongation regulates the composition and size of PGs in a manner that would cause low density lipoprotein (LDLs) retention in vessel wall. Galactosaminoglycans are a class of GAGs, commonly observed on PGs. Multiple enzymes are involved in galactosaminoglycan biosynthesis. Galactosaminoglycan synthesis is regulated by various signalling pathways which are amenable to pharmacological manipulation to treat atherosclerosis. Receptor mediated signalling pathways including protein tyrosine kinase receptors (PTKRs), serine/threonine kinase receptors (S/TKRs) and G-protein coupled receptors (GPCRs) pathways regulate galactosaminoglycan synthesizing enzyme expression. Increased expression of these enzymes modify galactosaminoglycan chain structure by making them hyperelongated. This review focuses on the signalling pathways regulating the expression of genes involved in galactosaminoglycan synthesis and modification. Furthermore, there are multiple other processes for inhibiting the interactions between LDL and galactosaminoglycans such as peptide mimetics of ApoB100 and anti-galactosaminoglycan antibodies and the therapeutic potential of these strategies is also addressed. (C) 2018 Elsevier Inc. All rights reserved.

KeywordAtherosclerosis Proteoglycans Galactosaminoglycans Signalling Pathways
DOI10.1016/j.pharmthera.2018.02.005
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000436218500007
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland 4102, Australia
2.Department of Pharmacy, Xinhua College of Sun Yat-sen University, Tianhe District, Guangzhou 510520, China
3.Kuliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan, Pahang 25200, Malaysia
4.Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland 4072, Australia
5.Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
6.Faculty of Health Sciences, University of Macau, Taipa, Macau, China
7.School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
Recommended Citation
GB/T 7714
Afroz, Rizwana,Cao, Yingnan,Rostam, Muhamad Ashraf,et al. Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis[J]. PHARMACOLOGY & THERAPEUTICS,2018,187:88-97.
APA Afroz, Rizwana.,Cao, Yingnan.,Rostam, Muhamad Ashraf.,Ta, Hang.,Xu, Suowen.,...&Little, Peter J..(2018).Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis.PHARMACOLOGY & THERAPEUTICS,187,88-97.
MLA Afroz, Rizwana,et al."Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis".PHARMACOLOGY & THERAPEUTICS 187(2018):88-97.
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