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Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer's Disease
Kosaraju, Jayasankar1; Holsinger, R. M. Damian2,3; Guo, Lixia4; Tam, Kin Yip1
2017-10
Source PublicationMOLECULAR NEUROBIOLOGY
ISSN0893-7648
Volume54Issue:8Pages:6074-6084
AbstractGlucagon-like peptide-1 (GLP-1) is an incretin hormone shown to be active in the treatment of type-2 diabetes (T2D) and has also been shown as efficacious in Alzheimer's disease (AD). Dipeptidyl peptidase-4 (DPP-4), an enzyme that is expressed in numerous cells, rapidly inactivates endogenous GLP-1. Therefore, DPP-4 inhibition is employed as a therapeutic avenue to increase GLP-1 levels in the management of T2D. The effectiveness of DPP-4 inhibitors in the treatment of AD has been reported in various animal models of AD. With this background, the present study was designed to examine the effectiveness of linagliptin, a DPP-4 inhibitor in the 3xTg-AD mouse model of Alzheimer's disease. Ninemonth- old 3xTg-AD mice were administered linagliptin orally (5, 10, and 20 mg/kg) for 8 weeks. At the end of the linagliptin treatment, mice were evaluated for cognitive ability on the Morris Water Maze and Y-maze. Following cognitive evaluation, mice were sacrificed to determine the effect of the linagliptin on brain incretin levels, amyloid burden, tau phosphorylation, and neuroinflammation. We confirm that linagliptin treatment for 8 weeks mitigates the cognitive deficits present in 3xTg-AD mice. Moreover, linagliptin also improves brain incretin levels and attenuates amyloid beta, tau phosphorylation as well as neuroinflammation. In conclusion, linagliptin possesses neuroprotective properties that may be attributed to the improvement of incretin levels in the brain.
KeywordGlucagon-like peptide-1 Glucose-dependent insulinotropic polypeptide Amyloid beta Tau phosphorylation Neuroinflammation
DOI10.1007/s12035-016-0125-7
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000409039000027
PublisherHUMANA PRESS INC
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Univ Macau, Drug Dev Core, Fac Hlth Sci, Taipa, Macao, Peoples R China;
2.Univ Sydney, Lab Mol Neurosci & Dementia, Brain & Mind Ctr, Camperdown, NSW 2050, Australia;
3.Univ Sydney, Discipline Biomed Sci, Sch Med Sci, Sydney Med Sch, Lidcombe, NSW 1875, Australia;
4.Chongqing Technol & Business Univ, Chongqing Key Lab Nat Med Res, Chongqing 400067, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Kosaraju, Jayasankar,Holsinger, R. M. Damian,Guo, Lixia,et al. Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer's Disease[J]. MOLECULAR NEUROBIOLOGY,2017,54(8):6074-6084.
APA Kosaraju, Jayasankar,Holsinger, R. M. Damian,Guo, Lixia,&Tam, Kin Yip.(2017).Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer's Disease.MOLECULAR NEUROBIOLOGY,54(8),6074-6084.
MLA Kosaraju, Jayasankar,et al."Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer's Disease".MOLECULAR NEUROBIOLOGY 54.8(2017):6074-6084.
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