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Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls
Zhang, Zhifang1,2,3; Yan, Tongjun4,5; Wang, Yanyan4,5; Zhang, Qiumei1,2,3,6; Zhao, Wan1,2,3; Chen, Xiongying1,2,3; Zhai, Jinguo6; Chen, Min6; Du, Boqi1,2,3; Deng, Xiaoxiang1,2,3; Ji, Feng6; Xiang, Yutao7,8; Wu, Hongjie9; Song, Jie9; Dong, Qi1,2,3; Chen, Chuansheng10; Li, Jun1,2,3
2018
Source PublicationNEUROIMAGE-CLINICAL
ISSN2213-1582
Volume19Pages:160-166
AbstractMIR137 gene has been repeatedly reported as a schizophrenia risk gene in genome-wide association studies (GWAS). A polymorphism (rs1625579) at the MIR137 gene has been associated with both neural activation and behavioral performance during a working memory task. This study examined MIR137' s associations with task-related (N-back working memory) fMRI, resting state fMRI, and diffusion tensor images (DTI) data in 177 healthy adults. We found less deactivation of the PCC in risk allele homozygotes (TT) as compared to the GT heterozygotes (cluster size = 630 voxels, cluster level P-FWE < 0.001) during the N-back task, which replicated previous findings. Using the identified cluster within the PCC as the seed, we further found decreased functional connectivity between the PCC and the anterior cingulate cortex and its adjacent medial prefrontal cortex (ACC/MPFC) in risk allele homozygotes during both resting state (cluster size = 427 voxels, cluster level P-FWE = 0.001) and the N-back task (cluster size = 73 voxels, cluster level P-FWE = 0.05). Finally, an analysis of our DTI data showed decreased white matter integrity of the posterior cingulum in risk allele homozygotes (cluster size = 214 voxels, cluster level P-FWE = 0.03). Taken together, rs1625579 seems to play an important role in both functional and structural connectivity between the PCC and the ACC/MPFC, which may serve as the brain mechanisms for the link between rs1625579 and schizophrenia.
KeywordMIR137 gene Working memory Functional connectivity Structural connectivity Posterior cingulate cortex
DOI10.1016/j.nicl.2018.03.039
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000441936300018
PublisherELSEVIER SCI LTD
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China;
2.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China;
3.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing, Peoples R China;
4.PLA 102nd Hosp, Changzhou 213003, Peoples R China;
5.Mental Hlth Ctr Mil, Changzhou 213003, Peoples R China;
6.Jining Med Univ, Sch Mental Hlth, 45 Jianshe South Rd, Jining 272013, Shandong, Peoples R China;
7.Beijing Anding Hosp, Beijing 100088, Peoples R China;
8.Univ Macau, Fac Hlth Sci, Ave Univ, Taipa, Macao, Peoples R China;
9.Shengli Petr Adm Bur, Shengli Hosp, Dongying 257022, Shandong, Peoples R China;
10.Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA
Recommended Citation
GB/T 7714
Zhang, Zhifang,Yan, Tongjun,Wang, Yanyan,et al. Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls[J]. NEUROIMAGE-CLINICAL,2018,19:160-166.
APA Zhang, Zhifang.,Yan, Tongjun.,Wang, Yanyan.,Zhang, Qiumei.,Zhao, Wan.,...&Li, Jun.(2018).Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls.NEUROIMAGE-CLINICAL,19,160-166.
MLA Zhang, Zhifang,et al."Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls".NEUROIMAGE-CLINICAL 19(2018):160-166.
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