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Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015
Zhang, Jinglu1; Han, Run1; Chen, Weijie1; Zhang, Weixiang1; Li, Ying2; Ji, Yuanhui3; Chen, Lijiang4; Pan, Hao4; Yang, Xinggang5; Pan, Weisan5; Ouyang, Defang1
2018-07
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:7
Abstract

Background: Solid dispersions are an effective formulation technique to improve the solubility, dissolution rate, and bioavailability of water-insoluble drugs for oral delivery. In the last 15 years, increased attention was focused on this technology. There were 23 marketed drugs prepared by solid dispersion techniques. Objective: This study aimed to report the big picture of solid dispersion research from 1980 to 2015. Method: Scientific knowledge mapping tools were used for the qualitative and the quantitative analysis of patents and literature from the time and space dimensions. Results: Western Europe and North America were the major research areas in this field with frequent international cooperation. Moreover, there was a close collaboration between universities and industries, while research collaboration in Asia mainly existed between universities. The model drugs, main excipients, preparation technologies, characterization approaches and the mechanism involved in the formulation of solid dispersions were analyzed via the keyword burst and co-citation cluster techniques. Integrated experimental, theoretical and computational tools were useful techniques for in silico formulation design of the solid dispersions. Conclusions: Our research provided the qualitative and the quantitative analysis of patents and literature of solid dispersions in the last three decades.

KeywordSolid Dispersion Big Data Literature Patent Scientific Knowledge Mapping Citespace
DOI10.3390/molecules23071697
URLView the original
Indexed BySCI ; SSCI ; SSCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000445301800200
PublisherMDPI
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi, Ying; Ouyang, Defang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, China
2.Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China
3.Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China
4.School of Pharmacy, Liaoning University, Shenyang 110000, China
5.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110000, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhang, Jinglu,Han, Run,Chen, Weijie,et al. Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015[J]. MOLECULES,2018,23(7).
APA Zhang, Jinglu.,Han, Run.,Chen, Weijie.,Zhang, Weixiang.,Li, Ying.,...&Ouyang, Defang.(2018).Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015.MOLECULES,23(7).
MLA Zhang, Jinglu,et al."Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015".MOLECULES 23.7(2018).
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