UM
A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression
Yang H.; Ma V.P.-Y.; Chan D.S.-H.; He H.-Z.; Leung C.-H.; Ma D.-L.
2013
Source PublicationCurrent Medicinal Chemistry
ISSN9298673
Volume20Issue:4Pages:576
AbstractA new cyclometallated iridium(III) complex with the 2,2'-biquinoline N-donor ligand has been synthesized and characterized. The interaction and affinity of the complex towards c-myc G-quadruplex and duplex DNA have been investigated using UV/Vis spectroscopy and gel mobility shift assay. These studies revealed that complex 1 binds to c-myc G-quadruplexes (Pu22 and Pu27) with high affinity but does not interact with duplex DNA either by intercalation or groove binding. The ability of 1 to stabilize c-myc G-quadruplex DNA in vitro has also been examined through a PCR stop assay and a cell-based luciferase reporter assay. Complex 1 displays promising cytotoxic activity against the HeLa cell line with sub-micromolar potency. © 2013 Bentham Science Publishers.
KeywordC-myc DNA G-quadruplex Iridium(III) Metal complex Oncogene Promoter
URLView the original
Language英语
The Source to ArticleScopus
Fulltext Access
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Yang H.,Ma V.P.-Y.,Chan D.S.-H.,et al. A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression[J]. Current Medicinal Chemistry,2013,20(4):576.
APA Yang H.,Ma V.P.-Y.,Chan D.S.-H.,He H.-Z.,Leung C.-H.,&Ma D.-L..(2013).A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression.Current Medicinal Chemistry,20(4),576.
MLA Yang H.,et al."A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression".Current Medicinal Chemistry 20.4(2013):576.
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