UM
Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-alpha and TGF-beta
Huang, Chengliang; Wu, Xu; Wang, Shengpeng; Wang, Wenjun; Guo, Fang; Chen, Yuanyuan; Pan, Bi; Zhang, Ming; Fan, Xianming
2018-07-04
Source PublicationCHINESE MEDICINE
ISSN1749-8546
Volume13
AbstractBackground: Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The freguently used immunosuppressive therapies such as dexamethasone (DEX) are often associated with side effects Recently, combination of two Chinese herbal medicine preparations, Salvia miltiorrhiza and ligustrazine (SML), serves as an alternative medicine for treatment of IPF in clinical practices in China. The aim of this study is to compare the anti-fibrotic effect of SML with that of DEX and to investigate the underlying mechanisms.
KeywordLigustrazine Pulmonary fibrosis Salvia miltiorrhiza SMAD4 TNF-alpha
DOI10.1186/s13020-018-0194-9
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000437440300002
PublisherBMC
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Huang, Chengliang,Wu, Xu,Wang, Shengpeng,et al. Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-alpha and TGF-beta[J]. CHINESE MEDICINE,2018,13.
APA Huang, Chengliang.,Wu, Xu.,Wang, Shengpeng.,Wang, Wenjun.,Guo, Fang.,...&Fan, Xianming.(2018).Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-alpha and TGF-beta.CHINESE MEDICINE,13.
MLA Huang, Chengliang,et al."Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-alpha and TGF-beta".CHINESE MEDICINE 13(2018).
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