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Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes
Lihua Lu1; Hai-Jing Zhong2; Modi Wang1; See-Lok Ho1; Hung-Wing Li1; Chung-Hang Leung2; Dik-Lung Ma1
2015
Source PublicationScientific Reports
ISSN20452322
Volume5
Abstract

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ 1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ 1-40 peptide on the basis of their emission response.

DOI10.1038/srep14619
URLView the original
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000361945100001
The Source to ArticleScopus
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation
GB/T 7714
Lihua Lu,Hai-Jing Zhong,Modi Wang,et al. Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes[J]. Scientific Reports,2015,5.
APA Lihua Lu.,Hai-Jing Zhong.,Modi Wang.,See-Lok Ho.,Hung-Wing Li.,...&Dik-Lung Ma.(2015).Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes.Scientific Reports,5.
MLA Lihua Lu,et al."Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes".Scientific Reports 5(2015).
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