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Forsythiae Fructus Inhibits B16 Melanoma Growth Involving MAPKs/Nrf2/HO-1 Mediated Anti-Oxidation and Anti-Inflammation
Bao J.1; DIng R.2; Zou L.3; Zhang C.1; Wang K.1; Liu F.1; Li P.1; Chen M.1; Wan J.-B.1; Su H.1; Wang Y.1; He C.1
2016
Source PublicationAmerican Journal of Chinese Medicine
ISSN0192415X
Volume44Issue:5Pages:1043
Abstract

Forsythiae Fructus, the fruits of Forsythia suspensa (Thunb.) Vahl, Lianqiao in Chinese, is one of the most fundamental herbs in traditional Chinese medicine (TCM). It is a typical heat-clearing and detoxicating herb, according to TCM theory. In this study, we investigated the antitumor effect of Forsythiae Fructus aqueous extract (FAE) on B16-F10 melanoma cells in vivo. The transplanted B16-F10 melanoma in C57BL/6 mice was established and used for the evaluation of the in vivo antitumor effect of FAE. FAE strongly inhibited the growth of B16-F10 cells in vitro and the tumor in vivo. The survival time of tumor-bearing mice was significantly prolonged by FAE. FAE inhibited cancer cell proliferation and angiogenesis in the tumor, as indicated by the decreased expressions of Ki67 and CD31. The levels of ROS, MDA, TNF-α and IL-6 decreased, while GSH increased in the FAE treatment group, indicating FAE possesses strong anti-oxidative and anti-inflammatory activity. The expression of anti-oxidant proteins Nrf-2 and HO-1, tumor suppressors P53 and p-PTEN, and the MAPK pathways in tumor tissues were upregulated by FAE treatment. These data demonstrated that FAE exhibited strong antitumor activity against B16-F10 murine melanoma both in vitro and in vivo. The antitumor effect of FAE involved decreases in oxidative stress and inflammation in the tumor, which is closely related to the heat-clearing and detoxicating properties of FAE. © 2016 World Scientific Publishing Company.

KeywordAnti-inflammation Anti-oxidation Antitumor B16 Melanoma Forsythia Suspensa Mapks/nrf2/ho-1 Pathway
DOIhttp://doi.org/10.1142/S0192415X16500580
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000382715400010
The Source to ArticleScopus
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Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, P.R. China
2.Faculty of Health Sciences, University of Macau, Macao 999078, P.R. China
3.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Bao J.,DIng R.,Zou L.,et al. Forsythiae Fructus Inhibits B16 Melanoma Growth Involving MAPKs/Nrf2/HO-1 Mediated Anti-Oxidation and Anti-Inflammation[J]. American Journal of Chinese Medicine,2016,44(5):1043.
APA Bao J..,DIng R..,Zou L..,Zhang C..,Wang K..,...&He C..(2016).Forsythiae Fructus Inhibits B16 Melanoma Growth Involving MAPKs/Nrf2/HO-1 Mediated Anti-Oxidation and Anti-Inflammation.American Journal of Chinese Medicine,44(5),1043.
MLA Bao J.,et al."Forsythiae Fructus Inhibits B16 Melanoma Growth Involving MAPKs/Nrf2/HO-1 Mediated Anti-Oxidation and Anti-Inflammation".American Journal of Chinese Medicine 44.5(2016):1043.
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