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An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB
Kang T.-S.1; Wang W.2; Zhong H.-J.1; Dong Z.-Z.2; Huang Q.3; Mok S.W.F.3; Leung C.-H.1; Wong V.K.W.3; Ma D.-L.2
2017
Source PublicationCancer Letters
ISSN3043835
Volume396Pages:76
Abstract

Four benzofuran-conjugated iridium(III) or rhodium (III)-based metal complexes are synthesized to screen as an inhibitor of STAT3 activity in prostate cancer cells. All complexes show the high stability and solubility in the biological system. In this study, an iridium(III) complex engages STAT3 and NF-κB to inhibit their translocation and transcriptional activities. Moreover, complex 1 shows more potential antiproliferative activity against DU145 cells and suppresses tumor growth in a prostate cancer xenograft mouse without observable adverse effects. Complex 1 may provide the basis for developing new therapeutic strategy in vivo and in vitro for the treatment of advanced prostate cancer. © 2017 Elsevier B.V.

KeywordBenzofuran-conjugated Iridium(Iii) Complex Dual Inhibitors Nf-κb Prostate Cells Stat3
DOI10.1016/j.canlet.2017.03.016
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000400715200008
The Source to ArticleScopus
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Cited Times [WOS]:29   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeung C.-H.; Wong V.K.W.; Ma D.-L.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Kang T.-S.,Wang W.,Zhong H.-J.,et al. An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB[J]. Cancer Letters,2017,396:76.
APA Kang T.-S..,Wang W..,Zhong H.-J..,Dong Z.-Z..,Huang Q..,...&Ma D.-L..(2017).An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB.Cancer Letters,396,76.
MLA Kang T.-S.,et al."An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB".Cancer Letters 396(2017):76.
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