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Comparison of sterols and fatty acids in two species of Ganoderma
Lv G.-P.1,2; Zhao J.1,2; Duan J.-A.3; Tang Y.-P.3; Li S.-P.1,2
2012
Source PublicationChemistry Central Journal
ISSN1752153X
Volume6Issue:1
Abstract

Background: Two species of Ganoderma, G. sinense and G. lucidum, are used as Lingzhi in China. Howerver, the content of triterpenoids and polysaccharides, main actives compounds, are significant different, though the extracts of both G. lucidum and G. sinense have antitumoral proliferation effect. It is suspected that other compounds contribute to their antitumoral activity. Sterols and fatty acids have obvious bioactivity. Therefore, determination and comparison of sterols and fatty acids is helpful to elucidate the active components of Lingzhi.Results: Ergosterol, a specific component of fungal cell membrane, was rich in G. lucidum and G. sinense. But its content in G. lucidum (median content 705.0 μg·g -1, range 189.1-1453.3 μg·g -1, n = 19) was much higher than that in G. sinense (median content 80.1 μg·g -1, range 16.0-409.8 μg·g -1, n = 13). Hierarchical clustering analysis based on the content of ergosterol showed that 32 tested samples of Ganoderma were grouped into two main clusters, G. lucidum and G. sinense. Hierarchical clustering analysis based on the contents of ten fatty acids showed that two species of Ganoderma had no significant difference though two groups were also obtained. The similarity of two species of Ganoderma in fatty acids may be related to their antitumoral proliferation effect.Conclusions: The content of ergosterol is much higher in G. lucidum than in G. sinense. Palmitic acid, linoleic acid, oleic acid, stearic acid are main fatty acids in Ganoderma and their content had no significant difference between G. lucidum and G. sinense, which may contribute to their antitumoral proliferation effect. © 2010 Guang-ping et al.

DOI10.1186/1752-153X-6-10
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000300842300001
The Source to ArticleScopus
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR 999078, China
2.Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China
3.Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
First Author AffilicationUniversity of Macau;  Institute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Lv G.-P.,Zhao J.,Duan J.-A.,et al. Comparison of sterols and fatty acids in two species of Ganoderma[J]. Chemistry Central Journal,2012,6(1).
APA Lv G.-P.,Zhao J.,Duan J.-A.,Tang Y.-P.,&Li S.-P..(2012).Comparison of sterols and fatty acids in two species of Ganoderma.Chemistry Central Journal,6(1).
MLA Lv G.-P.,et al."Comparison of sterols and fatty acids in two species of Ganoderma".Chemistry Central Journal 6.1(2012).
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