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Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation
Wang L.1; Li H.2; Wang S.1; Liu R.2; Wu Z.3; Wang C.1; Wang Y.1; Chen M.1
2014
Source PublicationAAPS PharmSciTech
ISSN15309932
Volume15Issue:4Pages:834
Abstract

Berberine hydrochloride (BH) is an isoquinolin alkaloid with promising anticancer efficacies. Nevertheless, further development and application of this compound had been hampered by its poor aqueous solubility, low gastrointestinal absorption, and rapid metabolism in the body. In this study, a solid lipid nanoparticle (SLN)-based system was developed for efficient incorporation and persistent release of BH. The drug-loading SLNs (BH-loaded SLNs) were stable, with a mean particle size of 81.42±8.48 nm and zeta potential of -28.67±0.71 mV. BH-loaded SLNs showed desirable drug entrapment efficiency and drug-loaded, and the release of BH from SLNs was significantly slower than free BH. Importantly, our in vitro study indicated that BH-loaded SLNs more significantly inhibited cell proliferation on MCF-7, HepG 2, and A549 cancer cells. Meanwhile, clone formation, cellular uptake, cell cycle arrest, and cell apoptosis studies also demonstrated that BH-loaded SLNs enhanced the antitumor efficacies of BH on MCF-7 cancer cells. Taken together, our results suggest that this SLN formulation may serve as a novel, simple, and efficient system for the delivery of BH. © 2014 American Association of Pharmaceutical Scientists.

KeywordAntitumor Evaluation Apoptosis Berberine Hydrochloride Solid Lipid Nanoparticles
DOI10.1208/s12249-014-0112-0
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000342489700004
The Source to ArticleScopus
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Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang C.; Chen M.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences,University of Macau,Taipa,China
2.State Key Laboratory of Respiratory Diseases,First Affiliated Hospital of Guangzhou Medical College,Guangzhou,China
3.Beijing University of Chinese Medicine,Beijing,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang L.,Li H.,Wang S.,et al. Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation[J]. AAPS PharmSciTech,2014,15(4):834.
APA Wang L..,Li H..,Wang S..,Liu R..,Wu Z..,...&Chen M..(2014).Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation.AAPS PharmSciTech,15(4),834.
MLA Wang L.,et al."Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation".AAPS PharmSciTech 15.4(2014):834.
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