UM
Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis
Chi, Liandi; Chen, Lingxiao; Zhang, Jiwen; Zhao, Jing; Li, Shaoping; Zheng, Ying
2018-07-15
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN0731-7085
Volume156Pages:125-132
AbstractInulin-type fructooligosaccharides (FOS) purified from Morinda Officinalis, with degrees of polymerization (DP) from 3 to 9, have been approved in China as an oral prescribed drug for mild and moderate depression episode, while the stability and oral absorption of this FOS mixtures are largely unknown. As the main active component and quality control marker for above FOS, DP5 was selected as the representative FOS in this study. Desalting method by ion exchange resin was developed to treat bio-sample, followed by separation and quantification by high performance liquid chromatography-charged aerosol detector. Results showed that the DP5 was stepwisely hydrolyzed in simulated gastric fluid and gut microbiota, while maintained stable in intestinal fluid. DP5 has poor permeability across Caco-2 monolayer with P-app of 5.22 x 10(-7) cm/s, and very poor oral absorption with bioavailability of (0.50 +/- 0.12)% in rat. In conclusion, FOS in Morinda Officinalis demonstrated poor chemical stability in simulated gastric fluid and human gut microbiota, and low oral absorption in rats. (C) 2018 Elsevier B.V. All rights reserved.
Keywordlnulin-type fructooligosaccharides (FOS) Morindo Officinalis Stability Absorption Bioavailability Gut microbiota
DOI10.1016/j.jpba.2018.04.028
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS IDWOS:000435228400014
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Document TypeJournal article
CollectionUniversity of Macau
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Chi, Liandi,Chen, Lingxiao,Zhang, Jiwen,et al. Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2018,156:125-132.
APA Chi, Liandi,Chen, Lingxiao,Zhang, Jiwen,Zhao, Jing,Li, Shaoping,&Zheng, Ying.(2018).Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,156,125-132.
MLA Chi, Liandi,et al."Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 156(2018):125-132.
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