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MPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer
Wang S.; Chen R.; Morott J.; Repka M.A.; Wang Y.; Chen M.
2015
Source PublicationExpert Opinion on Drug Delivery
ISSN17425247
Volume12Issue:3Pages:361
Abstract

Objective: Drug resistance remains a major challenge for effective breast cancer chemotherapy. Resveratrol (Res) is a promising candidate for overcoming cancer chemoresistance, but it has low bioavailability due to poor absorption, and ready metabolism limits its application. This study aims to develop a Res-loaded mixed micelle system to be effective on drug resistance of breast cancer cells. Methods: A mixed micelle system made of methoxy poly (ethylene glycol)-b-polycaprolactone (mPEG-PCL) and d-a-Tocopherol polyethylene glycol succinate was prepared and Res was encapsulated to form Res-loaded mixed micelles. Furthermore, the antitumor activity against doxorubicin (Dox)-resistant breast cancer MCF-7/ADR cells was studied and the possible mechanism was elucidated. Results: The mixed micellar formulation increased drug uptake efficiency of Res by Dox-resistant breast cancer MCF-7/ADR cells, and induced higher rates of apoptotic cell death, as assessed by the accumulation of Sub G1 phases of cell cycle, nucleus staining and Annexin-FITC/propidium iodide assay. Moreover, Res-loaded mixed micelles also markedly enhanced Dox-induced cytotoxicity in MCF-7/ADR cells and increased the cellular accumulation of Dox by downregulating the expression of P-glycoprotein (P-gp) and inhibiting the activity thereof. Conclusion: The cumulative evidence indicates that Res-loaded mixed micelles hold significant promise for the treatment of drug-resistant breast cancer.

KeywordBreast Cancer Resistance Mixed Micelles Mpeg-b-pcl Resveratrol Tocopherol Polyethylene Glycol Succinate
DOIhttp://doi.org/10.1517/17425247.2014.951634
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000349980300003
The Source to ArticleScopus
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被引频次[WOS]:29   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
AffiliationUniversity of Macau, Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
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Wang S.,Chen R.,Morott J.,et al. MPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer[J]. Expert Opinion on Drug Delivery,2015,12(3):361.
APA Wang S.,Chen R.,Morott J.,Repka M.A.,Wang Y.,&Chen M..(2015).MPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer.Expert Opinion on Drug Delivery,12(3),361.
MLA Wang S.,et al."MPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer".Expert Opinion on Drug Delivery 12.3(2015):361.
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