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Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α
Kang T.-S.1; Mao Z.2; Ng C.-T.1; Wang M.2; Wang W.2; Wang C.1; Lee S.M.-Y.1; Wang Y.1; Leung C.-H.1; Ma D.-L.2
2016
Source PublicationJournal of Medicinal Chemistry
ISSN222623
Volume59Issue:8Pages:4026
Abstract

The novel iridium(III) complex 1 was verified as a potent inhibitor of the TNF-α-TNFR protein-protein interaction in vitro and in cellulo. The iridium(III) center plays a critical role in organizing the structure of the bioactive metal complex, as the isolated ligands were found to be completely inactive. Both iridium enantiomers inhibited TNF-α-induced NF-κB activity and TNF-α-TNFR binding. 1 represents a promising scaffold for the further development of more potent organometallic TNF-α inhibitors. © 2016 American Chemical Society.

DOI10.1021/acs.jmedchem.6b00112
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000375519900031
The Source to ArticleScopus
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Cited Times [WOS]:28   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeung C.-H.; Ma D.-L.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, P. R. China
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Kang T.-S.,Mao Z.,Ng C.-T.,et al. Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α[J]. Journal of Medicinal Chemistry,2016,59(8):4026.
APA Kang T.-S..,Mao Z..,Ng C.-T..,Wang M..,Wang W..,...&Ma D.-L..(2016).Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α.Journal of Medicinal Chemistry,59(8),4026.
MLA Kang T.-S.,et al."Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α".Journal of Medicinal Chemistry 59.8(2016):4026.
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