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Adiponectin and breast cancer
Chen X.; Wang Y.
2011
Source PublicationMedical Oncology
ISSN13570560
Volume28Issue:4Pages:1288
Abstract

Adiponectin, an adipose tissue-derived hormone, has been studied intensively for the past decade because of its anti-inflammatory, anti-atherogenic, and anti-diabetic properties. Recent advances suggest that adiponectin also plays an important role in the development and progression of various cancers, especially obesity-related cancers. In this review, the authors focus on the potential role of adiponectin in breast cancer, an obesity- and endocrine-associated tumor. Epidemiological studies have shown that plasma adiponectin level is a risk factor for breast cancer in post-menopausal women. Adiponectin and its receptors are expressed on both breast cancer line cells and tumor tissues. Furthermore, exogenous adiponectin has exhibited therapeutic potential in animal models. Underlying mechanisms include the inhibition of cell proliferation and promotion of apoptosis, the regulation of tumorigenic-related factors, and the suppression of angiogenesis. The signaling pathways linking adiponectin with tumorigenesis might provide potential drug targets for the future. However, more convincing evidence is needed to fully elucidate the exact role of adiponectin in breast cancer, since both its beneficial effects and possible mechanisms remain controversial. © 2010 Springer Science+Business Media, LLC.

KeywordAdiponectin Adiponectin Receptor Apoptosis-angiogenesis Breast Cancer Proliferation
DOIhttp://doi.org/10.1007/s12032-010-9617-x
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000297256400052
The Source to ArticleScopus
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Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationInstitute of Chinese Medical SciencesUniversity of MacauMacauChina
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen X.,Wang Y.. Adiponectin and breast cancer[J]. Medical Oncology,2011,28(4):1288.
APA Chen X.,&Wang Y..(2011).Adiponectin and breast cancer.Medical Oncology,28(4),1288.
MLA Chen X.,et al."Adiponectin and breast cancer".Medical Oncology 28.4(2011):1288.
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