UM  > 中華醫藥研究院
Quality evaluation of lentinan injection produced in China
Chen Y.W.1; Hu D.J.1; Cheong K.L.1; Li J.1; Xie J.1; Zhao J.1; Li S.P.1,2
2013
Source PublicationJournal of Pharmaceutical and Biomedical Analysis
ISSN7317085
Volume78-79Pages:176
Abstract

Lentinan is a β-(1. →. 6) branched β-(1. →. 3)-glucan derived from Lentinula edodes mushroom. It has been developed as an adjuvant to cancer chemotherapy and clinically used in Japan and China. Up to date, six lentinan injections or powders for injection produced by individual manufacturers were widely used in clinic in China. Since antitumor effect of lentinan is highly related to its structure, conformation and molecular weight, quality evaluation of lentinan injection produced in China is crucial to ensure its efficacy, which has never been performed. In this study, absolute molecular weights and their distributions of lentinan in multiple batches of injections from different manufacturers in China were firstly determined through a high performance size exclusive chromatography (HPSEC) combined with multiple angle light scattering detection (MALSD) and refractive index detection (RID). Enzymatic (β-1,3- d-glucanase) digestion characters and triple helical conformation of lentinan were also investigated. The results showed that quality consistency of lentinan injections from different manufacturers in China was poor, which should be greatly improved to ensure their safety and efficacy. © 2013 Elsevier B.V.

KeywordHpsec-rid-malsd Lentinan Injection Molecular Weight Quality Evaluation Saccharide Mapping
DOIhttp://doi.org/10.1016/j.jpba.2013.02.012
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS IDWOS:000317442800027
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:32   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhao J.; Li S.P.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Macao
2.School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen Y.W.,Hu D.J.,Cheong K.L.,et al. Quality evaluation of lentinan injection produced in China[J]. Journal of Pharmaceutical and Biomedical Analysis,2013,78-79:176.
APA Chen Y.W..,Hu D.J..,Cheong K.L..,Li J..,Xie J..,...&Li S.P..(2013).Quality evaluation of lentinan injection produced in China.Journal of Pharmaceutical and Biomedical Analysis,78-79,176.
MLA Chen Y.W.,et al."Quality evaluation of lentinan injection produced in China".Journal of Pharmaceutical and Biomedical Analysis 78-79(2013):176.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen Y.W.]'s Articles
[Hu D.J.]'s Articles
[Cheong K.L.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen Y.W.]'s Articles
[Hu D.J.]'s Articles
[Cheong K.L.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen Y.W.]'s Articles
[Hu D.J.]'s Articles
[Cheong K.L.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.