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Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor
Li S.1; Chen H.1; Yang X.1; Bardelang D.2; Wyman I.W.3; Wan J.1; Lee S.M.Y.1; Wang R.1
2015
Source PublicationACS Medicinal Chemistry Letters
ISSN19485875
Volume6Issue:12Pages:1174
Abstract

Cucurbit[7]uril (CB[7]) was found in vitro to sequester the neurotoxins MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP+ (N-methyl-4-phenylpyridine). The CB[7]/neurotoxin host-guest complexes were studied in detail with 1H NMR, electrospray ionization mass spectrometry, UV-visible spectroscopic titration, and molecular modeling by density functional theory. The results supported the macrocyclic encapsulation of MPTP and MPP+, respectively, by CB[7] in aqueous solutions with relatively strong affinities and 1:1 host-guest binding stoichiometries in both cases. More importantly, the progression of MPTP/MPP+ induced neurodegeneration (often referred to as a Parkinson's disease model) was observed to be strongly inhibited in vivo by the synthetic CB[7] receptor, as shown in zebrafish models. These results show that a supramolecular approach could lead to a new preventive and/or therapeutic strategy for counteracting the deleterious effects of some neurotoxins leading to neurodegeneration. © 2015 American Chemical Society.

KeywordCucurbituril Inhibition Neurodegeneration Neurotoxin Supramolecular Complexation
DOIhttp://doi.org/10.1021/acsmedchemlett.5b00372
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000366343400001
The Source to ArticleScopus
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被引频次[WOS]:28   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorBardelang D.; Wang R.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
2.Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire, UMR 7273, 13013 Marseille, France
3.Department of Chemistry, Queen’s University, Kingston, ON K7L 3N6, Canada
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Li S.,Chen H.,Yang X.,et al. Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor[J]. ACS Medicinal Chemistry Letters,2015,6(12):1174.
APA Li S..,Chen H..,Yang X..,Bardelang D..,Wyman I.W..,...&Wang R..(2015).Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor.ACS Medicinal Chemistry Letters,6(12),1174.
MLA Li S.,et al."Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor".ACS Medicinal Chemistry Letters 6.12(2015):1174.
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