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In vivo reversal of general anesthesia by cucurbit[7]uril with zebrafish models
Huanxian Chen1; Judy Y. W. Chan1; Shengke Li1; Jessica J. Liu2; Ian W. Wyman2; Simon M. Y. Lee1; Donal H. Macartney.2; Ruibing Wang1
2015
Source PublicationRSC Advances
ISSN20462069
Volume5Issue:78Pages:63745-63752
Abstract

A general anesthetic is a drug that brings about a reversible loss of consciousness, during a surgical or therapeutic procedure to render the patient free of pain and anxiety. However, the effect of anesthetics may linger far beyond the necessary time required and induce adverse effects. In addition, many surgical patients need to recover to a conscious state that allows them to make important decisions soon after their surgery. Unfortunately, there are currently no clinically-available anti-dotes to reverse the effects of anesthetics. In this study, we demonstrate the in vitro supramolecular host-guest complexations between macrocyclic cucurbit[7]uril (CB[7]) and a commonly used general anesthetic in fish, tricaine mesylate (TM), and we report for the first time the in vivo reversal effect of CB[7] to general anesthesia induced by TM with zebrafish models. These findings might lead to a new approach that may allow patients to regain lucidity much faster than their natural recovery from general anesthesia, and may also be used to reverse potentially life-threatening toxic effects encountered by some patients in response to general anesthesia. 

DOI10.1039/c5ra09406b
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000358734800072
The Source to ArticleScopus
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Cited Times [WOS]:40   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorRuibing Wang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China
2.Department of Chemistry, Queen's University, Kingston, ON K7L 3N6, Canada
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huanxian Chen,Judy Y. W. Chan,Shengke Li,et al. In vivo reversal of general anesthesia by cucurbit[7]uril with zebrafish models[J]. RSC Advances,2015,5(78):63745-63752.
APA Huanxian Chen.,Judy Y. W. Chan.,Shengke Li.,Jessica J. Liu.,Ian W. Wyman.,...&Ruibing Wang.(2015).In vivo reversal of general anesthesia by cucurbit[7]uril with zebrafish models.RSC Advances,5(78),63745-63752.
MLA Huanxian Chen,et al."In vivo reversal of general anesthesia by cucurbit[7]uril with zebrafish models".RSC Advances 5.78(2015):63745-63752.
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