UM  > 中華醫藥研究院
Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis
Bin-Rui Yang1; Kwok-Kuen Cheung3; Xin Zhou2; Rui-Fang Xie2; Pei-Pei Cheng2; Shen Wu2; Zhong-Yan Zhou1,2; Jing Yi Tang2; Pui Man Hoi1; You-Hua Wang2; Simon Ming-Yuen Lee1
2016
Source PublicationJournal of Ethnopharmacology
ISSN3788741
Volume181Pages:50
Abstract

Ethnopharmacological relevance The root of Panax notoginseng is traditionally used as an anti-hemorrhagic agent to promote blood circulation without causing "congealed" blood. Furthermore, the flower of P. notoginseng is a popular, traditional medicine taken daily for the preventing of hypertension and for reducing blood cholesterol profiles. Besides, the flower of P. notoginseng contains a higher level of saponins, particularly protopanaxadiol-type ginsenosides, as compared to the root. However, detailed pharmacological studies on this flower have rarely been conducted. Material and methods In this study, the saponins extracted from the flower of P. notoginseng (FS) were examined on the endothelial cell migration assay, chemically induced vascular insufficiency model in zebrafish larvae and myocardial infraction (MI) model in rats, for determination of their pro-angiogenic and therapeutic effects on MI treatment. Results Our results demonstrate that FS significantly promoted VEGF-induced migration of human umbilical vein endothelial cells (HUVECs) and partially restored defective intersegmental vessels (ISV) in a chemically induced vascular insufficiency model of zebrafish larvae. When compared to MI group, two weeks post-treatment of FS (25-50 mg/kg/day) induced approximately 3-fold upregulation of VEGF mRNA expression and a concomitant increase in blood vessel density in the peri-infarct area of the heart. Moreover, TUNEL analysis indicates a reduction in the mean apoptotic nuclei per field in peri-infarct myocardium upon FS treatment. Conclusions The pro-angiogenic effects of FS demonstrated in in vitro and in vivo experimental models suggest that the purified saponin preparation from flowers of P. notoginseng may potentially provide preventive and therapeutic agent for cardiovascular diseases.

KeywordAngiogenesis Apoptosis Myocardial Infarction Panax Notoginseng Flower Saponin
DOI10.1016/j.jep.2016.01.022
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000372761500006
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYou-Hua Wang; Simon Ming-Yuen Lee
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
3.Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Bin-Rui Yang,Kwok-Kuen Cheung,Xin Zhou,et al. Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis[J]. Journal of Ethnopharmacology,2016,181:50.
APA Bin-Rui Yang.,Kwok-Kuen Cheung.,Xin Zhou.,Rui-Fang Xie.,Pei-Pei Cheng.,...&Simon Ming-Yuen Lee.(2016).Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis.Journal of Ethnopharmacology,181,50.
MLA Bin-Rui Yang,et al."Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis".Journal of Ethnopharmacology 181(2016):50.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Bin-Rui Yang]'s Articles
[Kwok-Kuen Cheung]'s Articles
[Xin Zhou]'s Articles
Baidu academic
Similar articles in Baidu academic
[Bin-Rui Yang]'s Articles
[Kwok-Kuen Cheung]'s Articles
[Xin Zhou]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Bin-Rui Yang]'s Articles
[Kwok-Kuen Cheung]'s Articles
[Xin Zhou]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.