UM
Discovery of a natural product-like c-myc G-Quadruplex DNA groove-binder by molecular docking
Ma D.-L.; Chan D.S.-H.; Fu W.-C.; He H.-Z.; Yang H.; Yan S.-C.; Leung C.-H.
2012
Source PublicationPLoS ONE
ISSN19326203
Volume7Issue:8
AbstractThe natural product-like carbamide (1) has been identified as a stabilizer of the c-myc G-quadruplex through high-throughput virtual screening. NMR and molecular modeling experiments revealed a groove-binding mode for 1. The biological activity of 1 against the c-myc G-quadruplex was confirmed by its ability to inhibit Taq polymerase-mediated DNA extension and c-myc expression in vitro, demonstrating that 1 is able to control c-myc gene expression at the transcriptional level presumably through the stabilization of the c-myc promoter G-quadruplex. Furthermore, the interaction between carbamide analogues and the c-myc G-quadruplex was also investigated by in vitro experiments in order to generate a brief structure-activity relationship (SAR) for the observed potency of carbamide 1. © 2012 Ma et al.
DOI10.1371/journal.pone.0043278
URLView the original
Language英语
The Source to ArticleScopus
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Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Ma D.-L.,Chan D.S.-H.,Fu W.-C.,et al. Discovery of a natural product-like c-myc G-Quadruplex DNA groove-binder by molecular docking[J]. PLoS ONE,2012,7(8).
APA Ma D.-L..,Chan D.S.-H..,Fu W.-C..,He H.-Z..,Yang H..,...&Leung C.-H..(2012).Discovery of a natural product-like c-myc G-Quadruplex DNA groove-binder by molecular docking.PLoS ONE,7(8).
MLA Ma D.-L.,et al."Discovery of a natural product-like c-myc G-Quadruplex DNA groove-binder by molecular docking".PLoS ONE 7.8(2012).
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