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Prognostic significance of minichromosome maintenance proteins in breast cancer
Kwok H.F.1,2,4; Zhang S.-D.4; McCrudden C.M.4; Yuen H.-F.3,4; Ting K.-P.5; Wen Q.4; Khoo U.-S.5; Chan K.Y.-K.5
2015
Source PublicationAmerican Journal of Cancer Research
ISSN21566976
Volume5Issue:1Pages:52-71
Abstract

A role for the minichromosome maintenance (MCM) proteins in cancer initiation and progression is slowly emerging. Functioning as a complex to ensure a single chromosomal replication per cell cycle, the six family members have been implicated in several neoplastic disease states, including breast cancer. Our study aim to investigate the prognostic significance of these proteins in breast cancer. We studied the expression of MCMs in various datasets and the associations of the expression with clinicopathological parameters. When considered alone, high level MCM4 overexpression was only weakly associated with shorter survival in the combined breast cancer patient cohort (n = 1441, Hazard Ratio = 1.31; 95% Confidence Interval = 1.11-1.55; p = 0.001). On the other hand, when we studied all six components of the MCM complex, we found that overexpression of all MCMs was strongly associated with shorter survival in the same cohort (n = 1441, Hazard Ratio = 1.75; 95% Confidence Interval = 1.31-2.34; p < 0.001), suggesting these MCM proteins may cooperate to promote breast cancer progression. Indeed, their expressions were significantly correlated with each other in these cohorts. In addition, we found that increasing number of overexpressed MCMs was associated with negative ER status as well as treatment response. Together, our findings are reproducible in seven independent breast cancer cohorts, with 1441 patients, and suggest that MCM profiling could potentially be used to predict response to treatment and prognosis in breast cancer patients.

KeywordBreast Cancer Minichromosome Maintenance Complex Prognosis Survival
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000348300400004
The Source to ArticleScopus
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Cited Times [WOS]:35   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorKhoo U.-S.; Chan K.Y.-K.
Affiliation1.Faculty of Health Sciences, University of Macau, Avenida de Universidade, Macau, China
2.CRUK Cambridge Institute, University of Cambridge, United Kingdom CB2 0RE
3.Institute of Molecular and Cell Biology, A*STAR, Singapore
4.Center for Cancer Research and Cell Biology (CCRCB) and School of Pharmacy, Queen’s University Belfast, United Kingdom BT9 7BL
5.Department of Pathology and Obsterics & Gyneecology, University of Hong Kong, Hong Kong, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Kwok H.F.,Zhang S.-D.,McCrudden C.M.,et al. Prognostic significance of minichromosome maintenance proteins in breast cancer[J]. American Journal of Cancer Research,2015,5(1):52-71.
APA Kwok H.F..,Zhang S.-D..,McCrudden C.M..,Yuen H.-F..,Ting K.-P..,...&Chan K.Y.-K..(2015).Prognostic significance of minichromosome maintenance proteins in breast cancer.American Journal of Cancer Research,5(1),52-71.
MLA Kwok H.F.,et al."Prognostic significance of minichromosome maintenance proteins in breast cancer".American Journal of Cancer Research 5.1(2015):52-71.
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