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Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
Ardah M.T.; Paleologou K.E.; Lv G.; Menon S.A.; Abul Khair S.B.; Lu J.-H.; Safieh-Garabedian B.; Al-Hayani A.A.; Eliezer D.; Li M.; El-Agnaf O.M.A.
2015
Source PublicationNeurobiology of Disease
ISSN9699961
Volume74Pages:89
AbstractCompelling evidence indicates that α-synuclein (α-syn) aggregation plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. Identification of compounds that inhibit or reverse the aggregation process may thus represent a viable therapeutic strategy against PD and related disorders. Ginseng is a well-known medicinal plant that has been used in East Asia for more than two thousand years to treat several conditions. It is now understood that the pharmacological properties of ginseng can be attributed to its biologically active components, the ginsenosides, which in turn have been shown to have neuroprotective properties. We therefore sought to determine for the first time, the potential of the most frequently used and studied ginsenosides, namely Rg1, Rg3 and Rb1, as anti-amyloidogenic agents. The effect of Rg1, Rg3 and Rb1 on α-syn aggregation and toxicity was determined by an array of biophysical, biochemical and cell-culture-based techniques. Among the screened ginsenosides, only Rb1 was shown to be a potent inhibitor of α-syn fibrillation and toxicity. Additionally, Rb1 exhibited a strong ability to disaggregate preformed fibrils and to inhibit the seeded polymerization of α-syn. Interestingly, Rb1 was found to stabilize soluble non-toxic oligomers with no β-sheet content, that were susceptible to proteinase K digestion, and the binding of Rb1 to those oligomers may represent a potential mechanism of action. Thus, Rb1 could represent the starting point for designing new molecules that could be utilized as drugs for the treatment of PD and related disorders. © 2014 Elsevier Inc.
KeywordAggregation Amyloid fibrils Drug discovery Ginsenosides Parkinson's disease α-Synuclein
DOI10.1016/j.nbd.2014.11.007
URLView the original
Language英语
The Source to ArticleScopus
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Cited Times [WOS]:42   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Ardah M.T.,Paleologou K.E.,Lv G.,et al. Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils[J]. Neurobiology of Disease,2015,74:89.
APA Ardah M.T..,Paleologou K.E..,Lv G..,Menon S.A..,Abul Khair S.B..,...&El-Agnaf O.M.A..(2015).Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.Neurobiology of Disease,74,89.
MLA Ardah M.T.,et al."Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils".Neurobiology of Disease 74(2015):89.
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