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Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats
Wu J.-H.; Leung G.P.H.; Kwan Y.-W.; Sham T.-T.; Tang J.-Y.; Wang Y.-H.; Wan J.-B.; Lee S.M.Y.; Chan S.-W.
2013
Source PublicationJournal of Functional Foods
ISSN17564646
Volume5Issue:3Pages:1159
AbstractPanax notoginseng saponins (PNS) are major active constituents of P. notoginseng. This study investigated the mechanisms of the hypocholesterolaemic and atheroscleroprotective effects of PNS. It was found that treatment of PNS (30 or 100. mg/kg/day, p.o.) could significantly reduce elevated serum total cholesterol, triacylglycerol, low-density lipoprotein cholesterol and atherogenic index induced by feeding rats with high cholesterol diet for 28. days. High-density lipoprotein cholesterol could also be increased by PNS treatment. Additionally, PNS significantly enhanced the hypercholesterolaemia-induced reduction of superoxide dismutase activity in the liver. In hypercholesterolaemic rats, PNS significantly improved the endothelium-dependent vasodilatation, acetylcholine-induced nitric oxide production and endothelial nitric oxide synthase mRNA expression in a dose-dependent manner. It also significantly reversed the hypercholesterolaemia-induced changes in mRNA expressions of cholesterol 7α-hydroxylase and peroxisome proliferator-activated receptor α but not HMG-CoA reductase. The findings provided evidence for using PNS to prevent the development of hypercholesterolaemia and atherosclerosis. The hypocholesterolaemic activity of PNS is likely to be resulted from inducing the biosynthesis of bile acids from cholesterol and promoting the β-oxidation of fatty acids in the liver. The vasoprotective function of PNS may be brought about by increasing the gene expression of eNOS in endothelial cells, its antioxidative activity, or both. © 2013 Elsevier Ltd.
KeywordCholesterol Hypercholesterolaemia Panax notoginseng Rat Saponin
DOI10.1016/j.jff.2013.03.013
URLView the original
Language英语
The Source to ArticleScopus
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Wu J.-H.,Leung G.P.H.,Kwan Y.-W.,et al. Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats[J]. Journal of Functional Foods,2013,5(3):1159.
APA Wu J.-H..,Leung G.P.H..,Kwan Y.-W..,Sham T.-T..,Tang J.-Y..,...&Chan S.-W..(2013).Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats.Journal of Functional Foods,5(3),1159.
MLA Wu J.-H.,et al."Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats".Journal of Functional Foods 5.3(2013):1159.
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