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Developmental and organ-specific toxicity of cucurbit[7]uril: In vivo study on zebrafish models
Huanxian Chen1; Judy Y. W. Chan1; Xue Yang1; Ian W. Wyman2; David Bardelang3; Donal H. Macartney2; Simon M. Y. Lee1; Ruibing Wang1
2015
Source PublicationRSC Advances
ISSN20462069
Volume5Issue:38Pages:30067
Abstract

The macrocyclic molecular container cucurbit[7]uril (CB[7]), the most water-soluble homologue in the cucurbit[n]uril family (n = 5-8, 10, 14), has been evaluated for its in vivo toxicity profile, including its developmental toxicity such as its effect on hatching, growth and survival, as well as its potential organ-specific toxicities such as cardiotoxicity, hepatotoxicity, and locomotion and behavioral toxicity, using zebrafish models. The results revealed that CB[7] has measureable cardiotoxicity and locomotion and behavioral toxicity at concentrations of ∼500 μM or higher, and negligible developmental and hepatotoxicity at concentrations up to 750 μM, although extended exposure to CB[7] in the 500-750 μM concentration range induced the mortality of tested fish. These results demonstrate for the first time with live in vivo animal models that CB[7] has relatively low developmental and organic specific toxicity, and support further exploration of the use of CB[7] in biomedical research at sub-toxic concentrations. 

DOI10.1039/c5ra04335b
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000352789500060
The Source to ArticleScopus
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Cited Times [WOS]:40   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorRuibing Wang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
2.Department of Chemistry, Queen's University, Kingston, ON, Canada
3.Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire, UMR 7273, 13397 Marseille, France
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huanxian Chen,Judy Y. W. Chan,Xue Yang,et al. Developmental and organ-specific toxicity of cucurbit[7]uril: In vivo study on zebrafish models[J]. RSC Advances,2015,5(38):30067.
APA Huanxian Chen.,Judy Y. W. Chan.,Xue Yang.,Ian W. Wyman.,David Bardelang.,...&Ruibing Wang.(2015).Developmental and organ-specific toxicity of cucurbit[7]uril: In vivo study on zebrafish models.RSC Advances,5(38),30067.
MLA Huanxian Chen,et al."Developmental and organ-specific toxicity of cucurbit[7]uril: In vivo study on zebrafish models".RSC Advances 5.38(2015):30067.
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