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A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo
Jianjian Zhang1; Chuwen Li2; Rui Zhang1; Fengyuan Zhang1; Wei Liu1; Xiaoyan Liu1; Simon Ming-Yuen Lee2; Haixia Zhang1
2016
Source PublicationChemical Communications
ISSN13597345
Volume52Issue:13Pages:2679
Abstract

A novel near-infrared (NIR), turn-on fluorescence probe CyR containing a phosphinate group as a recognizing moiety for the selective detection of O2 - with a low limit of detection (LOD, 9.9 nM) was developed. CyR has good cell-membrane permeability, intracellular stability, and low cytotoxicity. In addition, we successfully applied the CyR to visualize O2 - in live zebrafish, mouse and, for the first time, in mouse liver.

DOI10.1039/c5cc09976e
URLView the original
Indexed BySCIE ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000369642800002
The Source to ArticleScopus
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Cited Times [WOS]:53   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHaixia Zhang
Affiliation1.State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
2.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation
GB/T 7714
Jianjian Zhang,Chuwen Li,Rui Zhang,et al. A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo[J]. Chemical Communications,2016,52(13):2679.
APA Jianjian Zhang.,Chuwen Li.,Rui Zhang.,Fengyuan Zhang.,Wei Liu.,...&Haixia Zhang.(2016).A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo.Chemical Communications,52(13),2679.
MLA Jianjian Zhang,et al."A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo".Chemical Communications 52.13(2016):2679.
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