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Effects of polysaccharides from different species of Dendrobium (Shihu) on macrophage function
Meng L.-Z.; Lv G.-P.; Hu D.-J.; Cheong K.-L.; Xie J.; Zhao J.; Li S.-P.
2013
Source PublicationMolecules
ISSN14203049
Volume18Issue:5Pages:5779
Abstract

Dendrobium spp. are precious medicinal plants, used in China for thousands of years as health foods and nutrients. Polysaccharides are the main effective ingredients in Dendrobium plants. In this study, the chemical characteristics and the effects of crude polysaccharides (CPs) from five species of Dendrobium on macrophage function were investigated and compared in vitro for the first time. Chemical characteristic studies showed that CPs from different species of Dendrobium were diverse, displaying widely varied Mw distributions and molar ratios of monosaccharides. Their effects on macrophage functions, such as promoting phagocytosis, release of NO and cytokines IL-1α, IL-6, IL-10 and TNF-α, were also different. Moreover, CPs from D. officinale, especially collected from Yunnan Province, exerted the strongest immunomodulatory activities and could be explored as a novel potential functional food. The diverse chemical characteristics of CPs from different species of Dendrobium might contribute to their varied effects on macrophage functions, which should be further investigated. © 1996-2013 MDPI AG (Basel, Switzerland).

KeywordDendrobium Immune Function Polysaccharides Raw 264.7 Macrophages
DOI10.3390/molecules18055779
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000319446900063
The Source to ArticleScopus
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Cited Times [WOS]:27   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Meng L.-Z.,Lv G.-P.,Hu D.-J.,et al. Effects of polysaccharides from different species of Dendrobium (Shihu) on macrophage function[J]. Molecules,2013,18(5):5779.
APA Meng L.-Z..,Lv G.-P..,Hu D.-J..,Cheong K.-L..,Xie J..,...&Li S.-P..(2013).Effects of polysaccharides from different species of Dendrobium (Shihu) on macrophage function.Molecules,18(5),5779.
MLA Meng L.-Z.,et al."Effects of polysaccharides from different species of Dendrobium (Shihu) on macrophage function".Molecules 18.5(2013):5779.
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