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Structural characterization, α-glucosidase inhibitory and DPPH scavenging activities of polysaccharides from guava
Zhang Z.1,2,3; Kong F.1; Ni H.4; Mo Z.5; Wan J.-B.6; Hua D.1; Yan C.1
2016
Source PublicationCarbohydrate Polymers
ISSN1448617
Volume144Pages:106
Abstract

To explore the chemicals responsible for the health benefits of guava, water-soluble polysaccharides were extracted including GP90 and P90. They exhibited excellent α-glucosidase inhibition activity with an EC50 of 2.27 μg/mL and 0.18 mg/mL. This suggests that their activities were 1379- and 17-fold higher than the positive control. The DPPH scavenging activities of GP90 was even higher than Vc at some concentrations. Upon further isolation, a novel polysaccharide termed GB90-1B was obtained. Monosaccharide analysis, methylation analysis, and NMR were used to analyze the structural characterization of GB90-1B. Structural analysis revealed that its backbone consisted of (1→5)-linked-α-l-arabinose, (1→2,3,5)-linked-α-l-arabinose and (1→3)-linked-α-l-arabinose. Branch linkages included (1→6)-linked-α-d-glucose, (1→)-linked-α-d-glucose and (1→)-linked-α-l-arabinose. The structure of the repeating unit of GP90-1B was predicted. © 2016 Elsevier Ltd. All rights reserved.

KeywordDpph Scavenging Activity Guava Polysaccharides Psidium Guajava Linn. Structure Α-glucosidase Inhibition Activity
DOI10.1016/j.carbpol.2016.02.030
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000373830700014
The Source to ArticleScopus
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Cited Times [WOS]:71   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYan C.
Affiliation1.College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
2.Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangzhou, China
3.Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province, Guangzhou 510006, China
4.XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi 830002, China
5.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
6.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation
GB/T 7714
Zhang Z.,Kong F.,Ni H.,et al. Structural characterization, α-glucosidase inhibitory and DPPH scavenging activities of polysaccharides from guava[J]. Carbohydrate Polymers,2016,144:106.
APA Zhang Z..,Kong F..,Ni H..,Mo Z..,Wan J.-B..,...&Yan C..(2016).Structural characterization, α-glucosidase inhibitory and DPPH scavenging activities of polysaccharides from guava.Carbohydrate Polymers,144,106.
MLA Zhang Z.,et al."Structural characterization, α-glucosidase inhibitory and DPPH scavenging activities of polysaccharides from guava".Carbohydrate Polymers 144(2016):106.
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