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Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines
Huang L.-L.1,2; Wan J.-B.1,3; Wang B.1; He C.-W.1,3; Ma H.1; Li T.-W.1; Kang J.X.1
2013
Source PublicationProstaglandins Leukotrienes and Essential Fatty Acids
ISSN9523278
Volume88Issue:5Pages:347
Abstract

Excessive alcohol consumption can lead to hepatic steatosis. Omega-3 (n-3) polyunsaturated fatty acids (PUFA) have been shown to be effective in reducing hepatic accumulation of triglycerides (TG) by downregulation of TG biosynthesis in the liver. The aim of this study was to examine whether supplementation with the n-3 PUFA, docosahexaenoic acid (DHA), can effectively reduce acute alcohol-induced hepatic steatosis. Acute alcohol-induced hepatic steatosis was generated in 9-week-old male mice (C57BL/6J) by oral gavage of ethanol (4.7. g/kg BW) diluted in water (60%, v/v), with or without DHA (250. mg/kg BW), every 12. h for 3 administrations. Compared to the control (ethanol-alone) group, animals supplemented with DHA were protected against ethanol-induced TG accumulation in the liver. Accordingly, hepatic stearoyl-CoA desaturase-1 (SCD-1) expression, serum alanine aminotransferase (ALT) activity, and the levels of inflammatory cytokines (such as IL-6 and TNF-α) in the liver were significantly reduced, whereas the expression of heme oxygenase-1 (HO-1), an enzyme that can improve cell survival in liver tissue, was markedly increased in DHA-supplemented mice compared to the control animals. There were no differences in serum TG level and hepatic production of reactive oxygen species (ROS) between the two groups. Our findings demonstrate that DHA supplementation protects against acute ethanol-induced hepatic steatosis, which may be associated with reduced expression of SCD-1 and inflammatory cytokines. © 2013 Elsevier Ltd.

KeywordAlcoholic Liver Disease Docosahexaenoic Acid Hepatic Steatosis Inflammatory Cytokines Stearoyl-coa Desaturase 1
DOI10.1016/j.plefa.2013.02.002
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology ; Endocrinology & Metabolism
WOS IDWOS:000319549600003
The Source to ArticleScopus
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Cited Times [WOS]:34   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorKang J.X.
Affiliation1.Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
2.Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
Recommended Citation
GB/T 7714
Huang L.-L.,Wan J.-B.,Wang B.,et al. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines[J]. Prostaglandins Leukotrienes and Essential Fatty Acids,2013,88(5):347.
APA Huang L.-L..,Wan J.-B..,Wang B..,He C.-W..,Ma H..,...&Kang J.X..(2013).Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines.Prostaglandins Leukotrienes and Essential Fatty Acids,88(5),347.
MLA Huang L.-L.,et al."Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines".Prostaglandins Leukotrienes and Essential Fatty Acids 88.5(2013):347.
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