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Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root
Jia X.1; Zhang C.1; Qiu J.1; Wang L.2; Bao J.1; Wang K.1; Zhang Y.1; Chen M.1; Wan J.1; Su H.1; Han J.2; He C.1
2015
Source PublicationCarbohydrate Polymers
ISSN1448617
Volume132Pages:67
Abstract

Three novel acidic polysaccharides termed PRM1, PRM3 and PRM5 were purified from Rhynchosia minima root using DEAE-52 cellulose and sephadex G-150 column chromatography. Their structures were characterized by ultraviolet (UV) and Fourier transform infrared (FTIR) spectrometry, gel permeation chromatography (GPC), gas chromatography-mass spectrometry (GC-MS), and differential scanning colorimeter (DSC) analysis. The uronic acid contents of PRM1, PRM3 and PRM5 were 30.7%, 12.7% and 47.7%, respectively. PRM1 (143.2 kDa), PRM3 (105.3 kDa) and PRM5 (162.1 kDa) were heteropolysaccharides because they were composed of arabinose, mannose, glucose and galactose. Their enthalpy values were 201.0, 111.0 and 206.8 J/g, respectively. PRM3 and PRM1 exhibited strong in vitro anticancer activity against lung cancer A549 and liver cancer HepG2 cells in a dose-dependent manner. These findings suggested that PRM1 and PRM3 could be potentially developed as natural anticancer agents. © 2015 Elsevier Ltd. All rights reserved.

KeywordAnticancer Polysaccharide Purification Rhynchosia Minima
DOI10.1016/j.carbpol.2015.05.059
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000361184900009
The Source to ArticleScopus
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Cited Times [WOS]:46   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHe C.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
2.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Jia X.,Zhang C.,Qiu J.,et al. Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root[J]. Carbohydrate Polymers,2015,132:67.
APA Jia X..,Zhang C..,Qiu J..,Wang L..,Bao J..,...&He C..(2015).Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root.Carbohydrate Polymers,132,67.
MLA Jia X.,et al."Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root".Carbohydrate Polymers 132(2015):67.
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