UM
Stereoselective interactions of lactic acid enantiomers with HSA: Spectroscopy and docking application
Mu, Hongtao; Chen, Shaohuan; Liu, Fengyin; Xiao, Jianbo; Huang, Hui; Zhang, Yuhua; Sun, Yuanming; Gao, Xiangyang; Lei, Hongtao; Yuan, Xuewen
2019-01
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume270Pages:429-435
AbstractLactic acid enantiomers, normally found in fermented food, are absorbed into the blood and interact with plasma carrier protein human serum albumin (HSA). Unveiling the effect on the function and structure of HSA during chiral interaction can give a better understanding of the different distribution activities of the two enantiomers. Multi-spectroscopic methods and molecular modelling techniques are used to study the interactions between lactic acid enantiomers and HSA. Time-resolved and steady-state fluorescence spectra manifest that the fluorescence quenching mechanism is mainly static in type, due to complex formation. Binding interactions, deduced by thermodynamic calculation, agree with the docking prediction. Docking results and kinetic constants represent chiral-recognizing discriminations consistently. The bindings of lactic acid enantiomers lead to some microenvironmental and slight conformational changes of HSA as shown by circular dichroism (CD), synchronous and three-dimensional fluorescence spectra. This investigation may yield useful information about the possible toxicity risk of lactic acid enantiomers to human health.
KeywordLactic acid isomers Human serum albumin Fluorescence spectroscopy Circular dichroism Docking simulation
DOI10.1016/j.foodchem.2018.07.135
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000443253200056
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Mu, Hongtao,Chen, Shaohuan,Liu, Fengyin,et al. Stereoselective interactions of lactic acid enantiomers with HSA: Spectroscopy and docking application[J]. FOOD CHEMISTRY,2019,270:429-435.
APA Mu, Hongtao.,Chen, Shaohuan.,Liu, Fengyin.,Xiao, Jianbo.,Huang, Hui.,...&Yuan, Xuewen.(2019).Stereoselective interactions of lactic acid enantiomers with HSA: Spectroscopy and docking application.FOOD CHEMISTRY,270,429-435.
MLA Mu, Hongtao,et al."Stereoselective interactions of lactic acid enantiomers with HSA: Spectroscopy and docking application".FOOD CHEMISTRY 270(2019):429-435.
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