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Activation of mouse macrophages and dendritic cells induced by polysaccharides from a novel Cordyceps sinensis fungus UM01
Meng L.-Z.1; Feng K.1; Wang L.-Y.1; Cheong K.-L.1; Nie H.2; Zhao J.1; Li S.-P.1
2014
Source PublicationJournal of Functional Foods
ISSN17564646
Volume9Issue:1Pages:242
Abstract

Cultivation of Cordyceps fungi is now the major means for production of Cordyceps materials. UM01 is a novel fungal strain isolated from natural Cordyceps sinensis. In this study, the chemical characters and the immunomodulatory activities of polysaccharides from cultured mycelia of UM01 (UM01 PS) were investigated. Chemical studies showed that UM01 PS had a wide MW distribution and they mainly contained glucose, mannose and galactose. (1→6)-α-D-glucosidic linkages were found in UM01 PS. Pharmacological results showed that UM01 PS promoted mouse RAW 264.7 macrophages proliferation, phagocytic activity, release of NO and multiple cytokines and chemokines. UM01 PS not only induced differentiation of RAW 264.7 macrophages into dendritic-like cells, but also promoted phenotypic and functional maturation of mouse JAWS II dendritic cells. UM01 PS has the potential to activate macrophage and dendritic cell functions. They might be explored as novel immunomodulatory foods as substitute for natural C.sinensis. © 2014 Elsevier Ltd.

KeywordCordyceps Sinensis Immunomodulatory Activity Jaws Ii Dendritic Cells Polysaccharides Raw 264.7 Macrophages Um01
DOIhttp://doi.org/10.1016/j.jff.2014.04.029
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000338271900025
The Source to ArticleScopus
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Cited Times [WOS]:38   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhao J.; Li S.-P.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.College of Pharmacy, Jinan University, Guangzhou 510632, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Meng L.-Z.,Feng K.,Wang L.-Y.,et al. Activation of mouse macrophages and dendritic cells induced by polysaccharides from a novel Cordyceps sinensis fungus UM01[J]. Journal of Functional Foods,2014,9(1):242.
APA Meng L.-Z..,Feng K..,Wang L.-Y..,Cheong K.-L..,Nie H..,...&Li S.-P..(2014).Activation of mouse macrophages and dendritic cells induced by polysaccharides from a novel Cordyceps sinensis fungus UM01.Journal of Functional Foods,9(1),242.
MLA Meng L.-Z.,et al."Activation of mouse macrophages and dendritic cells induced by polysaccharides from a novel Cordyceps sinensis fungus UM01".Journal of Functional Foods 9.1(2014):242.
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