UM  > 健康科學學院
Energy-Transfer Metal-Organic Nanoprobe for Ratiometric Sensing with Dual Response to Peroxynitrite and Hypochlorite
Ding, Zhaoyang; Wang, Chunfei; Feng, Gang; Zhang, Xuanjun
2018-08
Source PublicationACS OMEGA
ISSN2470-1343
Volume3Issue:8Pages:9400-9406
Abstract

An energy-transfer metal-organic nanoprobe is designed for ratiometric sensing with dual response to both peroxynitrite (ONOO-) and hypochlorite (ClO-). Here, a nanoscale metal-organic framework (NMOF) acts as the energy donor and molecular probe as the acceptor to construct a Forster-resonance energy transfer (FRET) nanosystem. Biocompatible dextran conveniently binds to the NMOF surface through multiple weak coordination interactions to improve water dispersibility and cell uptake. Dextran can also coordinate with the molecular probe with arylboronic acid group, which enables the convenient grafting of molecular probes to the NMOF surface to construct energy-transfer nanoprobes. Because of efficient FRET, the bright blue fluorescence of NMOF is quenched, whereas red emission from the acceptor is enhanced. Upon reacting with ONOO-, the probe departs from NMOF and the fluorescence of NMOF is recovered because of the interruption of FRET. When reacting with ClO-, the phenothiazine moiety in the molecular probe is oxidized into phenothiazine-5-oxide, which leads to more efficient energy transfer and the fluorescence shifts from red to orange. The nanoprobes are also successfully applied to the detection of ONOO- and ClO- in living cells.

DOI10.1021/acsomega.8b01489
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000444182900083
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniv Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Ding, Zhaoyang,Wang, Chunfei,Feng, Gang,et al. Energy-Transfer Metal-Organic Nanoprobe for Ratiometric Sensing with Dual Response to Peroxynitrite and Hypochlorite[J]. ACS OMEGA,2018,3(8):9400-9406.
APA Ding, Zhaoyang,Wang, Chunfei,Feng, Gang,&Zhang, Xuanjun.(2018).Energy-Transfer Metal-Organic Nanoprobe for Ratiometric Sensing with Dual Response to Peroxynitrite and Hypochlorite.ACS OMEGA,3(8),9400-9406.
MLA Ding, Zhaoyang,et al."Energy-Transfer Metal-Organic Nanoprobe for Ratiometric Sensing with Dual Response to Peroxynitrite and Hypochlorite".ACS OMEGA 3.8(2018):9400-9406.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ding, Zhaoyang]'s Articles
[Wang, Chunfei]'s Articles
[Feng, Gang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ding, Zhaoyang]'s Articles
[Wang, Chunfei]'s Articles
[Feng, Gang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ding, Zhaoyang]'s Articles
[Wang, Chunfei]'s Articles
[Feng, Gang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.