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Visualization of Zn2+ ions in live zebrafish using a luminescent iridium(III) chemosensor
Ma D.-L.1; He H.-Z.1; Zhong H.-J.2; Lin S.1; Chan D.S.-H.1; Wang L.2; Lee S.M.-Y.2; Leung C.-H.2; Wong C.-Y.3
Source PublicationACS Applied Materials and Interfaces

A novel luminescent cyclometalated iridium(III) complex-based chemosensor (1) bearing a zinc-specific receptor, tris(2-pyridylmethyl)amine, and the 3-phenyl-1H-pyrazole ligand has been designed and synthesized. Upon the addition of Zn2+ ions to a solution of iridium(III) complex 1, a pronounced luminescence color change from blue to green can be observed, which may be attributed to the suppression of photoinduced electron transfer upon complexation of complex 1 with Zn2+ ions. The interaction of iridium(III) complex 1 with Zn2+ ions was investigated by UV-vis absorption titration, emission titration, and 1H NMR titration. Furthermore, the iridium(III) complex 1 exhibited good selectivity for Zn 2+ over 13 other common metal ions, including K+, Ag +, Na+, Ni2+, Fe3+, Hg2+, Cd2+, Mg2+, Ca2+, Cu2+, Mn 2+, Co2+, and Pb2+ ions. The practical application of the iridium(III) complex 1 in visualizing intracellular Zn 2+ distribution in live zebrafish was also demonstrated. © 2014 American Chemical Society.

KeywordChemosensor Iridium(Iii) Complex Luminescent Zinc Ion
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Indexed BySCI
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000341122000084
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Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa D.-L.
Affiliation1.Department of Chemistry and Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
3.Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China
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GB/T 7714
Ma D.-L.,He H.-Z.,Zhong H.-J.,et al. Visualization of Zn2+ ions in live zebrafish using a luminescent iridium(III) chemosensor[J]. ACS Applied Materials and Interfaces,2014,6(16):14008.
APA Ma D.-L..,He H.-Z..,Zhong H.-J..,Lin S..,Chan D.S.-H..,...&Wong C.-Y..(2014).Visualization of Zn2+ ions in live zebrafish using a luminescent iridium(III) chemosensor.ACS Applied Materials and Interfaces,6(16),14008.
MLA Ma D.-L.,et al."Visualization of Zn2+ ions in live zebrafish using a luminescent iridium(III) chemosensor".ACS Applied Materials and Interfaces 6.16(2014):14008.
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