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Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine
Jiang Q.-W.1; Cheng K.-J.2,3; Mei X.-L.1; Qiu J.-G.1; Zhang W.-J.1; Xue Y.-Q.1; Qin W.-M.1; Yang Y.1; Zheng D.-W.1; Chen Y.1; Wei M.-N.1; Zhang X.3; Lv M.4; Chen M.-W.5; Wei X.1; Shi Z.1
2015
Source PublicationOncotarget
ISSN19492553
Volume6Issue:32Pages:32790
Abstract

Triptolide and celastrol are two main active compounds isolated from Thunder God Vine with the potent anticancer activity. However, the anticancer effect of triptolide in combination with celastrol is still unknown. In the present study, we demonstrated that the combination of triptolide with celastrol synergistically induced cell growth inhibition, cell cycle arrest at G2/M phase and apoptosis with the increased intracellular ROS accumulation in cancer cells. Pretreatment with ROS scavenger N-acetyl-L-cysteine dramatically blocked the apoptosis induced by co-treatment with triptolide and celastrol. Treatment with celastrol alone led to the decreased expressions of HSP90 client proteins including survivin, AKT, EGFR, which was enhanced by the addition of triptolide. Additionally, the celastrol-induced expression of HSP70 and HSP27 was abrogated by triptolide. In the nude mice with xenograft tumors, the lower-dose combination of triptolide with celastrol significantly inhibited the growth of tumors without obvious toxicity. Overall, triptolide in combination with celastrol showed outstanding synergistic anticancer effect in vitro and in vivo, suggesting that this beneficial combination may offer a promising treatment option for cancer patients.

KeywordCancer Celastrol Combination Therapy Triptolide
DOI10.18632/oncotarget.5411
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000363186600054
The Source to ArticleScopus
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Cited Times [WOS]:40   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong,
2.Chemical Biology Center, Lishui Institute of Agricultural Sciences, Lishui, Zhejiang, China
3.National First-Class Key Discipline for Traditional Chinese Medicine of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
4.Institute of Materia Medica, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
5.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Jiang Q.-W.,Cheng K.-J.,Mei X.-L.,et al. Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine[J]. Oncotarget,2015,6(32):32790.
APA Jiang Q.-W..,Cheng K.-J..,Mei X.-L..,Qiu J.-G..,Zhang W.-J..,...&Shi Z..(2015).Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.Oncotarget,6(32),32790.
MLA Jiang Q.-W.,et al."Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine".Oncotarget 6.32(2015):32790.
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