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Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene
Deng Y.-H.1,2; Alex D.1; Huang H.-Q.2; Wang N.1; Yu N.1; Wang Y.-T.1; Leung G.P.H.3; Lee S.M.-Y.1
2011
Source PublicationPhytotherapy Research
ISSN0951418X
Volume25Issue:3Pages:451
Abstract

Resveratrol (RSV) has been shown to have anti-inflammatory activity and to have a protective role against atherosclerosis. Here it is shown, for the first time, that its derivative trans-3,5,4′-trimethoxystilbene (TMS) may be a more potent anti-inflammatory agent than resveratrol.A comparative analysis of the inhibitory activities of related stilbenes, resveratrol, TMS and polydatin (PD), on monocyte adhesion to TNF-α-activated endothelial cells showed TMS to be the most effective, with PD being the least effective. RSV and its analogues inhibited, albeit differentially, the protein and mRNA expression levels of inducible cell adhesion molecules, ICAM-1 and VCAM-1, in cultured endothelial cells. The mechanism of the inhibitory effects of these stilbenes on endothelial cell-monocyte cell adhesion can be attributed mainly to inhibition of NF-κB pathway activation. The results demonstrate that all three investigated stilbene compounds, especially TMS, exhibit a potent inhibitory effect on inflammation-induced cell-cell adhesion, expression of adhesion molecules and activation of the NF-′B pathway. Copyright © 2010 John Wiley & Sons, Ltd.

KeywordCell Adhesion Molecules Inflammation Nf-′b Resveratrol Stilbene
DOIhttp://doi.org/10.1002/ptr.3279
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000288133000021
The Source to ArticleScopus
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Cited Times [WOS]:45   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira S.J., Taipa, Macao, China
2.School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
3.Department of Pharmacology and Pharmacy, the University of Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Deng Y.-H.,Alex D.,Huang H.-Q.,et al. Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene[J]. Phytotherapy Research,2011,25(3):451.
APA Deng Y.-H..,Alex D..,Huang H.-Q..,Wang N..,Yu N..,...&Lee S.M.-Y..(2011).Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene.Phytotherapy Research,25(3),451.
MLA Deng Y.-H.,et al."Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene".Phytotherapy Research 25.3(2011):451.
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