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Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats
Chen H.; Liao H.; Liu Y.; Zheng Y.; Wu X.; Su Z.; Zhang X.; Lai Z.; Lai X.; Lin Z.-X.; Su Z.
2015
Source PublicationFitoterapia
ISSN0367326X
Volume100Pages:110
AbstractWe examined the protective effect of pogostone (PO), a chemical constituent isolated from Pogostemonis Herba, on the ethanol-induced gastric ulcer in rats. Administration of PO at doses of 10, 20 and 40 mg/kg body weight prior to ethanol ingestion effectively protected the stomach from ulceration. The gastric lesions were significantly ameliorated by all doses of PO as compared to the vehicle group. Pre-treatment with PO prevented the oxidative damage and the decrease of prostaglandin E2 (PGE2) content. In addition, PO pretreatment markedly increased the mucosa levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), and decreased gastric malonaldehyde (MDA), relative to the vehicle group. In the mechanistic study, significant elevation of non-protein-sulfhydryl (NP-SH) was observed in the gastric mucosa pretreated by PO. Analysis of serum cytokines indicated that PO pretreatment obviously elevated the decrease of interleukin-10 (IL-10) level, while markedly mitigated the increment of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) secretions in ethanol-induced rats. Taken together, these results strongly indicate that PO could exert a gastro-protective effect against gastric ulceration, and the underlying mechanism might be associated with the stimulation of PGE2, improvement of antioxidant and anti-inflammatory status, as well as preservation of NP-SH. © 2014 Elsevier B.V. All rights reserved.
KeywordAnti-inflammatory Antioxidant Ethanol Gastric ulcer Pogostone Rats
DOI10.1016/j.fitote.2014.11.017
URLView the original
Language英语
The Source to ArticleScopus
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Cited Times [WOS]:41   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Chen H.,Liao H.,Liu Y.,et al. Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats[J]. Fitoterapia,2015,100:110.
APA Chen H..,Liao H..,Liu Y..,Zheng Y..,Wu X..,...&Su Z..(2015).Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats.Fitoterapia,100,110.
MLA Chen H.,et al."Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats".Fitoterapia 100(2015):110.
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