UM
Comparison of spray freeze drying and the solvent evaporation method for preparing solid dispersions of baicalein with pluronic F68 to improve dissolution and oral bioavailability
He X.; Pei L.; Tong H.H.Y.; Zheng Y.
2011
Source PublicationAAPS PharmSciTech
ISSN15309932
Volume12Issue:1Pages:104
AbstractThe objective of this study was to prepare solid dispersions consisting of baicalein and a carrier with a low glass transition/melting point (Pluronic F68) by spray freeze drying (SFD). We compared these powders to those produced from the conventional solvent evaporation method. In the SFD process, a feeding solution was atomized above the surface of liquid nitrogen following lyophilization, which resulted in instantaneously frozen microparticles. However, solid dispersions prepared by the solvent evaporation method formed a sticky layer on the glass flask with crystalline baicalein separated out from the carrier. The powder samples were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), surface area measurement, differential scanning calorimetry, and Fourier transform infrared spectrometry. SEM and PXRD results suggested that the majority of baicalein in the SFD-processed solid dispersion was in the amorphous state, which has a higher specific surface area than pure baicalein. However, the majority of baicalein was recrystallized in the solid dispersion at the same composition prepared by the solvent evaporation method, which showed a similar dissolution rate to the physical mixture. SFD product was physically and chemically stable after being stored at 40°C with low humidity for 6 months. After enzyme hydrolysis, baicalein in the SFD product displayed a significantly shorter T max and higher C max than pure baicalein after oral dosing. The relative bioavailability of the SFD product versus pure baicalein determined by comparing the AUC0-12 was 233%, which demonstrated the significantly improved oral bioavailability of baicalein produced by the SFD technique. © 2010 American Association of Pharmaceutical Scientists.
Keywordbaicalein bioavailability solid dispersion solvent evaporation (SE) spray freeze drying (SFD)
DOI10.1208/s12249-010-9560-3
URLView the original
Language英语
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:42   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
He X.,Pei L.,Tong H.H.Y.,et al. Comparison of spray freeze drying and the solvent evaporation method for preparing solid dispersions of baicalein with pluronic F68 to improve dissolution and oral bioavailability[J]. AAPS PharmSciTech,2011,12(1):104.
APA He X.,Pei L.,Tong H.H.Y.,&Zheng Y..(2011).Comparison of spray freeze drying and the solvent evaporation method for preparing solid dispersions of baicalein with pluronic F68 to improve dissolution and oral bioavailability.AAPS PharmSciTech,12(1),104.
MLA He X.,et al."Comparison of spray freeze drying and the solvent evaporation method for preparing solid dispersions of baicalein with pluronic F68 to improve dissolution and oral bioavailability".AAPS PharmSciTech 12.1(2011):104.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[He X.]'s Articles
[Pei L.]'s Articles
[Tong H.H.Y.]'s Articles
Baidu academic
Similar articles in Baidu academic
[He X.]'s Articles
[Pei L.]'s Articles
[Tong H.H.Y.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[He X.]'s Articles
[Pei L.]'s Articles
[Tong H.H.Y.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.