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In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer
Sun K.1; Tang Y.1; Li Q.1; Yin S.1; Qin W.1; Yu J.2; Chiu D.T.2; Liu Y.3; Yuan Z.3; Zhang X.3; Wu C.1
Source PublicationACS Nano

Small molecules participate extensively in various life processes. However, specific and sensitive detection of small molecules in a living system is highly challenging. Here, we describe in vivo real-time dynamic monitoring of small molecules by a luminescent polymer-dot oxygen transducer. The optical transducer combined with an oxygen-consuming enzyme can sensitively detect small-molecule substrates as the enzyme-catalyzed reaction depletes its internal oxygen reservoir in the presence of small molecules. We exemplify this detection strategy by using glucose-oxidase-functionalized polymer dots, yielding high selectivity, large dynamic range, and reversible glucose detection in cell and tissue environments. The transducer-enzyme assembly after subcutaneous implantation provides a strong luminescence signal that is transdermally detectable and continuously responsive to blood glucose fluctuations for up to 30 days. In view of a large library of oxygen-consuming enzymes, this strategy is promising for in vivo detection and quantitative determination of a variety of small molecules. © 2016 American Chemical Society.

KeywordDynamic Monitoring Fluorescent Nanoparticle In Vivo imagIng Semiconductor Polymer Dots Small Molecule
URLView the original
Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000380576600041
The Source to ArticleScopus
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Cited Times [WOS]:69   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, Jilin 130012, China
2.Department of Chemistry and Bioengineering, University of Washington, Seattle, Washington 98195, United States
3.Bioimaging Core, Faculty of Health Science, University of Macau, Taipa, Macau SAR China
Recommended Citation
GB/T 7714
Sun K.,Tang Y.,Li Q.,et al. In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer[J]. ACS Nano,2016,10(7):6769.
APA Sun K..,Tang Y..,Li Q..,Yin S..,Qin W..,...&Wu C..(2016).In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer.ACS Nano,10(7),6769.
MLA Sun K.,et al."In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer".ACS Nano 10.7(2016):6769.
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