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Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice
Shen, Shengnan; Liao, Qiwen; Huang, Li; Li, Dan; Zhang, Qingwen; Wang, Yitao; Lee, Simon Ming-Yuen; Lin, Ligen
2018-08
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume47Pages:192-199
AbstractThe seeds of Clausena lansium have been used to treat acute and chronic gastro-intestinal disorders. To further explore its therapeutic value on metabolic diseases, a water soluble fraction from ethanolic extract of C. lansium seeds (HP) was evaluated on a high-fat diet (HFD) induced obesity mice model. The mice were fed with HFD for 8 weeks to induce obesity, and then orally administrated with HP for 9 weeks. The results showed HP treatment retarded body weight and fat mass gain of mice under HFD feeding. Moreover, HP significantly improved lipid profile and insulin sensitivity in HFD fed mice. 16S rRNA sequencing indicated that HP mildly reversed HFD feeding induced imbalance of Firmicutes/Bacteroidetes ratio in gut. Taken together, HP protects mice from HFD induced metabolic disorders and restores gut microbiota balance, which might be well developed as novel functional food for anti-obesity and improvement of insulin sensitivity.
KeywordClausena lansium Fat mass gain Insulin sensitivity Gut microbiota Wampee
DOI10.1016/j.jff.2018.05.057
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000439019200022
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Shen, Shengnan,Liao, Qiwen,Huang, Li,et al. Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice[J]. JOURNAL OF FUNCTIONAL FOODS,2018,47:192-199.
APA Shen, Shengnan.,Liao, Qiwen.,Huang, Li.,Li, Dan.,Zhang, Qingwen.,...&Lin, Ligen.(2018).Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice.JOURNAL OF FUNCTIONAL FOODS,47,192-199.
MLA Shen, Shengnan,et al."Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice".JOURNAL OF FUNCTIONAL FOODS 47(2018):192-199.
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