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Metal complexes as potential modulators of inflammatory and autoimmune responses
Chung-Hang Leung1; Sheng Lin2; Hai-Jing Zhong1; Dik-Lung Ma2
2015
Source PublicationChemical Science
ISSN20416520
Volume6Issue:2Pages:871-884
Abstract

Over the past few decades, the realm of inorganic medicinal chemistry has been dominated by the study of the anti-cancer properties of transition metal complexes, particularly those based on platinum or ruthenium. However, comparatively less attention has been focused on the development of metal complexes for the treatment of inflammatory or autoimmune diseases. Metal complexes possess a number of advantages that render them as attractive alternatives to organic small molecules for the development of therapeutic agents. In this perspective, we highlight recent examples in the development of transition metal complexes as modulators of inflammatory and autoimmune responses. The studies presented here serve to highlight the potential of transition metal complexes in modulating inflammatory or immune pathways in cells.

DOI10.1039/c4sc03094j
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000348147100001
The Source to ArticleScopus
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Cited Times [WOS]:80   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChung-Hang Leung; Dik-Lung Ma
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chung-Hang Leung,Sheng Lin,Hai-Jing Zhong,et al. Metal complexes as potential modulators of inflammatory and autoimmune responses[J]. Chemical Science,2015,6(2):871-884.
APA Chung-Hang Leung,Sheng Lin,Hai-Jing Zhong,&Dik-Lung Ma.(2015).Metal complexes as potential modulators of inflammatory and autoimmune responses.Chemical Science,6(2),871-884.
MLA Chung-Hang Leung,et al."Metal complexes as potential modulators of inflammatory and autoimmune responses".Chemical Science 6.2(2015):871-884.
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