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Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation
Alex D.1; Leong E.C.1; Zhang Z.-J.1; Yan G.T.H.2; Cheng S.-H.2; Leong C.-W.1; Li Z.-H.1; Lam K.-H.1; Chan S.-W.3; Lee S.M.-Y.1
2010
Source PublicationJournal of Cellular Biochemistry
ISSN7302312
Volume109Issue:2Pages:339
Abstract

Angiogenesis plays an important role in the development of neoplastic diseases such as cancer. Resveratrol and its derivatives exert antiangiogenic effects, but the mechanisms of their actions remain unclear. The aim of this study was to evaluate the antiangiogenic activity of resveratrol and its derivative trans-3,5,4′-trimethoxystilbene in vitro using human umbilical vein endothelial cells (HUVECs) and in vivo using transgenic zebrafish, and to clarify their mechanisms of action in zebrafish by gene expression analysis of the vascular endothelial growth factor (VEGF) receptor (VEGFR2/KDR) and cell-cycle analysis. trans-3,5,4′-Trimethoxystilbene showed significantly more potent antiangiogenic activity than that of resveratrol in both assays. In zebrafish, trans-3,5,4′-trimethoxystilbene caused intersegmental vessel regression and downregulated VEGFR2 mRNA expression. Trans-3,5,4′- trimethoxystilbene also induced G2/M cell-cycle arrest, most specifically in endothelial cells of zebrafish embryos. We propose that the antiangiogenic and vascular-targeting activities of trans-3,5,4′-trimethoxystilbene result from the downregulation of VEGFR2 expression and cell-cycle arrest at G2/M phase. © 2009 Wiley-Liss, Inc.

Keyword3,5,4′-trimethoxystilbene Angiogenesis Cell Cycle Huvec Vegfr2 Zebrafish
DOI10.1002/jcb.22405
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000274471400008
The Source to ArticleScopus
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Cited Times [WOS]:44   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLee S.M.-Y.
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira S.J., Taipa, Macao SAR, China
2.Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China
3.State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Alex D.,Leong E.C.,Zhang Z.-J.,et al. Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation[J]. Journal of Cellular Biochemistry,2010,109(2):339.
APA Alex D..,Leong E.C..,Zhang Z.-J..,Yan G.T.H..,Cheng S.-H..,...&Lee S.M.-Y..(2010).Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation.Journal of Cellular Biochemistry,109(2),339.
MLA Alex D.,et al."Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation".Journal of Cellular Biochemistry 109.2(2010):339.
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