UM  > 健康科學學院
Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis
Zheng, Wei1; Zhang, Qing-E.2; Cai, Dong-Bin3; Ng, Chee H.4; Ungvari, Gabor S.5; Ning, Yu-Ping6; Xiang, Yu-Tao7
2018-08
Source PublicationJOURNAL OF PSYCHIATRIC RESEARCH
ISSN0022-3956
Volume103Pages:38-45
Abstract

Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66.7%) studies were rated as "high quality". Compared to healthy controls, CHR-P subjects showed impairment with large effect size in overall cognition (n = 128, SMD = 1.00, 95%CI: 1.38, 0.63, P < 0.00001; 12 = 2%), processing speed (SMD = 1.21) and attention/vigilance (SMD = 0.83), and with medium effect size in working memory (SMD = 0.76), reasoning and problem solving (SMD = 0.71), visual (SMD = 0.68) and verbal learning (SMD = 0.67). No significant difference between CHR-P subjects and controls was found regarding social cognition (SMD = 0.33, 95%CI: 0.76, 0.10, P = 0.14; 12 = 70%) with small effect size. Apart from social cognition, CHR-P subjects performed worse than healthy control in all MCCB cognitive domains, particularly in processing speed, attention/vigilance and working memory.

KeywordSchizophrenia Psychosis Clinical High Risk For Psychosis Neurocognitive Function Mccb Meta-analysis
DOIhttp://doi.org/10.1016/j.jpsychires.2018.05.001
URLView the original
Indexed BySCI ; SSCI ; SSCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000438004900007
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorNing, Yu-Ping; Xiang, Yu-Tao
Affiliation1.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
2.The National Clinical Research Center for Mental Disorders, China &Center of Depression, Beijing Institute for Brain Disorders & Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China.
3.Clinics of Chinese Medicine, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
4.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
5.The University of Notre Dame Australia/Graylands Hospital, Perth, Australia.
6.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
7.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zheng, Wei,Zhang, Qing-E.,Cai, Dong-Bin,et al. Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2018,103:38-45.
APA Zheng, Wei.,Zhang, Qing-E..,Cai, Dong-Bin.,Ng, Chee H..,Ungvari, Gabor S..,...&Xiang, Yu-Tao.(2018).Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis.JOURNAL OF PSYCHIATRIC RESEARCH,103,38-45.
MLA Zheng, Wei,et al."Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis".JOURNAL OF PSYCHIATRIC RESEARCH 103(2018):38-45.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zheng, Wei]'s Articles
[Zhang, Qing-E.]'s Articles
[Cai, Dong-Bin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zheng, Wei]'s Articles
[Zhang, Qing-E.]'s Articles
[Cai, Dong-Bin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng, Wei]'s Articles
[Zhang, Qing-E.]'s Articles
[Cai, Dong-Bin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.