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Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy
Da Zhang1,2,3; Hao Xu4,5; Xiaolong Zhang1,2; Yubin Liu5; Ming Wu1,2; Juan Li3; Huanghao Yang3; Gang Liu6; Xiaolong Liu1,2; Jingfeng Liu1,2,7; Zhen Yuan5
2018-08
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:30Pages:25203-25212
Abstract

The nanosized metal-organic particles (NMOPs) recently have attracted tremendous attentions in biomedical applications. However, few studies have developed metal-organic nanoparticles (NMOPs) as near-infrared (NIR) II phototherapeutic agents and as Fenton-like agents for cancer theranostics. Herein, directly using organic dye and Cu(II)-ion complexes to construct NMOPs, as dual-mode therapeutic agent for PA imaging-guided photochemotherapy in NIR II window, is reported. The NMOPs are simply an assembly of Cu(II) ion and tetrahydroxyanthraquinone (THQ) complexes [Cu(II)-THQ](n) through the coordination effect, van der Waals force, and pi-pi interactions. After modification of polyethylene glycol (PEG-(NH2)(2)), the obtained Cu- THQNPs endow excellent biocompatibility and stability in physiological conditions. Because of the strong absorption at NIR II window and photoinduced electrontransfer (PET) mechanism, the Cu-THQNPs not only acted as an excellent photothermal agent with extremely high light-to-heat conversion ability (51.34%) at 1064 nm for phototherapy but also explored as the PA contrast agent for precisely tracking and guiding the therapy in vivo. Most strikingly, our Cu-THQNPs can be degraded by tumor-specific acidic-cleaving of the coordination bonds and follow by the slow release of Cu(II) into tumors, which can act as Fenton-like agents to generate (OH)-O-center dot from H2O2 for enhancing the antitumor efficacy in vivo. With almost 100% prevention of the tumor growth for ca. 14 days and no obvious toxicity based on blood biochemical/histological analysis, this work highlights the Cu-THQNPs as an efficient NIR II therapeutic agent for precise cancer theranostics.

KeywordCopper(Ii) Organic Dye Metal-organic Nanoparticle The Second Near-infrared Window Phototheranostics Chemotherapy
DOI10.1021/acsami.8b08419
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000440956000029
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorXiaolong Liu; Jingfeng Liu
Affiliation1.The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China
2.The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China
3.The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350002, P. R. China
4.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China
5.Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau 999078 SAR, P. R. China
6.Center for Molecular Imaging and Translational Medicine, Xiamen University, Xiamen 361005, P. R. China
7.Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China
Recommended Citation
GB/T 7714
Da Zhang,Hao Xu,Xiaolong Zhang,et al. Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(30):25203-25212.
APA Da Zhang.,Hao Xu.,Xiaolong Zhang.,Yubin Liu.,Ming Wu.,...&Zhen Yuan.(2018).Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy.ACS APPLIED MATERIALS & INTERFACES,10(30),25203-25212.
MLA Da Zhang,et al."Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy".ACS APPLIED MATERIALS & INTERFACES 10.30(2018):25203-25212.
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