UM
Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy
Zhang, Da; Xu, Hao; Zhang, Xiaolong; Liu, Yubin; Wu, Ming; Li, Juan; Yang, Huanghao; Liu, Gang; Liu, Xiaolong; Liu, Jingfeng; Yuan, Zhen
2018-08
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:30Pages:25203-25212
AbstractThe nanosized metal-organic particles (NMOPs) recently have attracted tremendous attentions in biomedical applications. However, few studies have developed metal-organic nanoparticles (NMOPs) as near-infrared (NIR) II phototherapeutic agents and as Fenton-like agents for cancer theranostics. Herein, directly using organic dye and Cu(II)-ion complexes to construct NMOPs, as dual-mode therapeutic agent for PA imaging-guided photochemotherapy in NIR II window, is reported. The NMOPs are simply an assembly of Cu(II) ion and tetrahydroxyanthraquinone (THQ) complexes [Cu(II)-THQ](n) through the coordination effect, van der Waals force, and pi-pi interactions. After modification of polyethylene glycol (PEG-(NH2)(2)), the obtained Cu- THQNPs endow excellent biocompatibility and stability in physiological conditions. Because of the strong absorption at NIR II window and photoinduced electrontransfer (PET) mechanism, the Cu-THQNPs not only acted as an excellent photothermal agent with extremely high light-to-heat conversion ability (51.34%) at 1064 nm for phototherapy but also explored as the PA contrast agent for precisely tracking and guiding the therapy in vivo. Most strikingly, our Cu-THQNPs can be degraded by tumor-specific acidic-cleaving of the coordination bonds and follow by the slow release of Cu(II) into tumors, which can act as Fenton-like agents to generate (OH)-O-center dot from H2O2 for enhancing the antitumor efficacy in vivo. With almost 100% prevention of the tumor growth for ca. 14 days and no obvious toxicity based on blood biochemical/histological analysis, this work highlights the Cu-THQNPs as an efficient NIR II therapeutic agent for precise cancer theranostics.
Keywordcopper(II) organic dye metal-organic nanoparticle the second near-infrared window phototheranostics chemotherapy
DOI10.1021/acsami.8b08419
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000440956000029
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Zhang, Da,Xu, Hao,Zhang, Xiaolong,et al. Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(30):25203-25212.
APA Zhang, Da.,Xu, Hao.,Zhang, Xiaolong.,Liu, Yubin.,Wu, Ming.,...&Yuan, Zhen.(2018).Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy.ACS APPLIED MATERIALS & INTERFACES,10(30),25203-25212.
MLA Zhang, Da,et al."Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy".ACS APPLIED MATERIALS & INTERFACES 10.30(2018):25203-25212.
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