UM
Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis
Zhong Z.; Chen X.; Tan W.; Xu Z.; Zhou K.; Wu T.; Cui L.; Wang Y.
2011
Source PublicationEuropean Journal of Pharmacology
ISSN142999
Volume667Issue:2018-01-03Pages:50
AbstractTraditional medicinal herbs are an untapped source of potential pharmaceutical compounds. This study aims to determine whether the proliferation of breast cancer cell lines could be inhibited by germacrone, a natural product isolated from Rhizoma curcuma. Germacrone treatment significantly inhibited cell proliferation, increased lactate dehydrogenase (LDH) release, and induced mitochondrial membrane potential (ΔΨm) depolarization in both MCF-7 and MDA-MB-231 cells in a dose-dependent manner. Germacrone induced MDA-MB-231 and MCF-7 cell cycle arrest at the G0/G1 and G2/M phases respectively and induced MDA-MB-231 cell apoptosis. Furthermore, germacrone treatment significantly increased Bok expression and cytochrome c release from mitochondria without affecting Bcl-2, Bcl-xL, Bax, and Bim protein expressions. In addition, germacrone treatment induced caspase-3, 7, 9, PARP cleavage. We concluded that germacrone inhibited the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. These results might provide some molecular basis for the anti-tumor activity of Rhizoma curcuma. © 2011 Elsevier B.V. All rights reserved.
KeywordApoptosis Breast cancer Cell cycle Germacrone Proliferation
DOI10.1016/j.ejphar.2011.03.041
URLView the original
Language英语
The Source to ArticleScopus
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Cited Times [WOS]:57   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Zhong Z.,Chen X.,Tan W.,et al. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis[J]. European Journal of Pharmacology,2011,667(2018-01-03):50.
APA Zhong Z..,Chen X..,Tan W..,Xu Z..,Zhou K..,...&Wang Y..(2011).Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis.European Journal of Pharmacology,667(2018-01-03),50.
MLA Zhong Z.,et al."Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis".European Journal of Pharmacology 667.2018-01-03(2011):50.
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